ALPHA-ACTIN REMODELING IN THE A7R5 SMOOTH MUSCLE CELL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 越来越清楚的是，除了滑动细丝理论之外，还有其他机制有助于平滑肌的收缩特性。我们和其他人提出，细胞骨架的重塑可能解释了平滑肌表现出的独特收缩特性。本项目的目的是确定收缩的A7r5细胞系中细胞骨架组织的变化与其收缩特性以及血管平滑肌收缩特性的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It has become increasingly clear that there are additional mechanisms additional to the sliding filament theory that contribute to the contractile properties of smooth muscle. Ourselves and others have proposed that remodelling of the cytoskeleton may explain the uniqie contractile properties exhibited by smooth muscle. The goal of this project is to determine the relationship of changes in organization of the cytoskeleton in the contracting A7r5 cell line to its contractile properties as well as contractile properties of vascular smooth muscle.