Gene Regulation

基因调控

• 批准号: 7944547
• 负责人: Stephen T Smale
• 金额: $ 6.08万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-02 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944547
• 关键词: Affect; Animal Model; Area; Cancer Center Support Grant; Cell Differentiation process; Development; Diagnosis; Fostering; Funding; Gene Expression Regulation; Gifts; Goals; Grant; Inflammation; Investments; Jonsson Comprehensive Cancer Center of University of California Los Angeles; Journals; Knowledge; Leadership; Letters; Malignant Neoplasms; Mammalian Cell; Mediating; Methodology; Molecular; National Cancer Institute; Peer Review; Physiological Processes; Process; Publications; Regulation; Research; Research Personnel; Resource Sharing; Resources; Science; Seeds; Series; Translations; Virus Latency; cancer initiation; cancer therapy; clinical application; college; cost; expectation; insight; interest; meetings; member; novel strategies; professor; programs; therapy development

The Gene Regulation Program Area is composed of 21 members, spanning 8 Departments within UCLA. In ;he past competing cycle, investigators from this Program authored 374 publications, of which 94 (25%) were nter-programmatic and 15 (4%) intra-programmatic. 155 (41%) were placed in high-impact journals. 15 members of this Program Area used 8 out of the 8 Shared Resources that are currently funded by the JCCC. During the current funding year, peer-reviewed funding totaled $12.2 million in total costs, including $1.6 million from the National Cancer Institute. As with other Program Areas, JCCC fosters a number of interactive activities and many of the Shared Resources that support investigators in the GR Program Area. During the current grant cycle, funds from the JCCC in the form of CCSG Developmental Funds, institutional support and philanthropic gifts to the GR Program Area total $832,185. These funds supported Interdisciplinary Grants, Seed Grants, recruitment/retention, Program Area Leadership support, funding for the use of emerging Shared Resources and trainees. Twelve of the Program Area Members were the recipients of JCCC support. The Gene Regulation Program Area is completing its first full CCSG cycle. The initial goal of the Program Area was to bring together the strong existing group of gene regulation researchers at UCLA and to develop a collective interest in the application of gene regulation studies to problems of cancer origin, development, and therapy. The original group of 12 has grown to 21 members, in large part by recruitment of a group of extraordinary young investigators as Assistant Professors. Substantial investment by the JCCC, the DGSoM, and the College of Letters and Science has benefited this Program Area enormously. During the current CCSG cycle, we have focused on four major objectives: (1) to promote among our members the study of fundamental mechanisms of gene regulation, using appropriate model organisms, mammalian cells, and animal models; (2) to study the molecular/transcriptional mechanisms that mediate cell differentiation, nflammation and viral latency and investigate how aberrations in these processes affect cancer initiation and progression; (3) to serve as a resource for the other Program Areas in the JCCC in the use of gene regulation concepts and methodologies to advance their research problems; and (4) to promote the translation of existing knowledge and new discoveries into translational and clinical applications. Interactions among members are fostered by a monthly meeting, a weekly journal club, and a seminar series that brings "leaders in the field" to UCLA.

基因调控计划领域由 21 名成员组成，涵盖 UCLA 的 8 个系。在 ;在过去的竞争周期中，该计划的研究人员撰写了 374 篇出版物，其中 94 篇 (25%) 程序间和程序内 15 个 (4%)。 155 篇 (41%) 被发表在高影响力期刊上。 15 该计划领域的成员使用了 JCCC 目前资助的 8 项共享资源中的 8 项。 在本资助年度，同行评审资助的总成本为 1220 万美元，其中 1.6 美元 来自国家癌症研究所的百万美元。与其他计划领域一样，JCCC 促进了许多互动 支持遗传资源计划领域研究人员的活动和许多共享资源。期间 当前的拨款周期、JCCC 以 CCSG 发展基金、机构支持和形式提供的资金 向 GR 计划领域提供的慈善捐款总额为 832,185 美元。这些资金支持跨学科赠款， 种子补助、招募/保留、计划领域领导力支持、为使用新兴共享资源提供资金 资源和学员。十二个计划领域成员获得了 JCCC 的支持。 基因调控计划领域即将完成其第一个完整的 CCSG 周期。该计划的最初目标 该领域的目标是将加州大学洛杉矶分校现有的强大基因调控研究小组聚集在一起，并开发一个 将基因调控研究应用于癌症起源、发展和癌症问题的集体兴趣 治疗。最初的 12 人小组已发展到 21 名成员，这在很大程度上是通过招募一群 杰出的年轻研究者担任助理教授。 JCCC、DGSoM 的大量投资 文理学院使该项目领域受益匪浅。当前期间 CCSG 周期中，我们重点关注四大目标： (1) 促进我们的会员学习 基因调控的基本机制，使用适当的模型生物体、哺乳动物细胞和 动物模型； (2) 研究介导细胞分化的分子/转录机制， 炎症和病毒潜伏期，并研究这些过程中的异常如何影响癌症的发生和发展 进展； (3) 作为JCCC其他计划领域在基因调控应用方面的资源 推进研究问题的概念和方法； (4) 促进现有文献的翻译 将知识和新发现转化为转化和临床应用。成员之间的互动是 通过每月一次的会议、每周一次的期刊俱乐部和一系列研讨会来促进“该领域的领导者” 加州大学洛杉矶分校。