DEVELOPMENT OF A RHESUS MONKEY MODEL FOR IN UTERO CHIKUNGUNYA VIRUS INFECTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 基孔肯雅病毒（CHIKV）是一种与人类衰弱性关节痛流行病相关的蚊媒甲病毒。从2005年到2007年，来自东非的CHIKV基因型传播到印度，导致爆发了200万人病例。除了疫情规模外，还发现了新的神经系统综合征，包括与新生儿传播相关的胎儿脑病。尚待确定的是，这些新的综合征是毒力增加、组织嗜性改变的结果，还是仅仅反映了疫情的规模和病例报告的改善。尽管最近已经开发了CHIKV小鼠模型，但非人灵长类动物具有更能反映人的生理特征，因此允许更准确地表示人CHIKV嗜性和临床综合征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of debilitating arthralgia in humans. From 2005-2007, a CHIKV genotype from East Africa crossed to India, leading to an outbreak with 2 million human cases reported. In addition to the outbreak magnitude, novel neurological syndromes were identified, including fetal encephalopathy associated with neonatal transmission. It remains to be determined whether the novel syndromes are the result of increased virulence, altered tissue tropism or are merely reflective of the outbreak size and improved case reporting. Although a CHIKV mouse model has recently been developed, non-human primates possess physiological characteristics more reflective of humans, thus allowing for a more accurate representation of human CHIKV tropism and clinical syndromes.