DEVELOPMENT OF A RHESUS MONKEY MODEL FOR IN UTERO CHIKUNGUNYA VIRUS INFECTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 基孔肯雅病毒(CHIKV)是一种蚊媒甲型病毒，与人类虚弱关节痛的流行有关。从2005年至2007年，来自东非的一种CHIKV基因型进入印度，导致暴发，报告了200万例人感染病例。除了暴发规模外，还发现了新的神经综合征，包括与新生儿传播相关的胎儿脑病。新的症状是否是毒力增强、组织趋向性改变的结果，还是仅仅反映了疫情规模和病例报告的改善，仍有待确定。虽然最近已经建立了CHIKV小鼠模型，但非人类灵长类动物具有更能反映人类的生理特征，因此可以更准确地代表人类CHIKV的嗜性和临床症状。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of debilitating arthralgia in humans. From 2005-2007, a CHIKV genotype from East Africa crossed to India, leading to an outbreak with 2 million human cases reported. In addition to the outbreak magnitude, novel neurological syndromes were identified, including fetal encephalopathy associated with neonatal transmission. It remains to be determined whether the novel syndromes are the result of increased virulence, altered tissue tropism or are merely reflective of the outbreak size and improved case reporting. Although a CHIKV mouse model has recently been developed, non-human primates possess physiological characteristics more reflective of humans, thus allowing for a more accurate representation of human CHIKV tropism and clinical syndromes.