Identification of Biomarkers for Response to Chemoprevention of Colon Cancer

对遗传性肥胖小鼠的新干预研究采用了一种以豆类为基础的饮食， 测试暴露于氧化偶氮甲烷后结肠癌发生的衰减。的 选择豆类饮食来模拟最近完成的息肉预防中的条件 在一项试验中，人类受试者消耗最高四分之一的豆类（海军，利马，肾脏， black等）显示晚期腺瘤（E.兰扎和同事们 2006年、2009年）。全豆和两种豆级分显示出减毒肿瘤的功效 多重性（Bobe等人，Nutr Ca 2008）。最近的研究表明， 炎症相关的细胞因子作为豆类饮食功效的指标（Mentor-Marcel等人， Prev Res 2009）。目前的研究旨在鉴定功能重要的分子 目标的豆类饮食的条件下的功效以及预测的生物标志物。基因 粪便结肠细胞的表达谱显示了2到3个基因的集合，其变化是 表明存在风险（Zhao et al Ca Prev Res 2009）。

New intervention studies in genetically obese mice employ a bean-based diet being tested for attenuation of colon carcinogenesis following exposure to azoxymethane. The bean-based diet was chosen to mimic conditions in the recently completed polyp prevention trial in which human subjects consuming the highest quartile of beans (navy, lima, kidney, black etc) showed a 3-fold reduction in ocurrence of advanced adenoma (E. Lanza and coworkers 2006, 2009). The whole beans and two bean fractions showed efficacy in attenuating tumor multiplicity (Bobe et al, Nutr Ca 2008). Recent studies have identified inflammation-associated cytokines as indicators of bean-diet efficacy (Mentor-Marcel et al Ca Prev Res 2009). Current studies are aimed at identifying funtionally significant molecular targets of the bean diets under conditions of efficacy as well as predictive biomarkers. Gene expression profiling of fecal colonocytes has revealed sets of 2 to 3 genes whose changes are indicative of risk (Zhao et al Ca Prev Res 2009).