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Genes associated with endocrine tumorigenesis

Genes associated with endocrine tumorigenesis
与内分泌肿瘤发生相关的基因
批准号：
7967843
负责人：
Sunita Agarwal
金额：
$92.71万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7967843
关键词：
AchievementCDK6-associated protein p18CDKN2A geneCandidate Disease GeneCategoriesCell Cycle ProgressionCell ProliferationCellsCyclin-Dependent Kinase InhibitorEmbryonic DevelopmentEndocrineEndocrine Gland NeoplasmsEventFamilyGenesGerm-Line MutationGoalsHistocompatibility TestingHomeostasisInheritedIslet Cell TumorIslets of LangerhansLifeMeninMolecularMolecular GeneticsMultiple Endocrine Neoplasia Type 1NeoplasmsRegulationRegulator GenesSyndromebasecell transformationinsightinterestmouse modelpositional cloningprotein protein interactiontumortumorigenesis

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相关文献

中文摘要
翻译
MEN1基因编码的menin功能失活可导致遗传性多发性内分泌肿瘤1型（MEN1）综合征和部分散发性胰腺内分泌肿瘤。因此，探索menin上游或下游的分子事件可以指出其他致病基因和/或负责此类肿瘤类型的调节事件。我们目前的工作方向是研究两类基因调控menin转录，转录后，蛋白：蛋白相互作用和亚细胞定位事件：1)周期蛋白依赖性激酶抑制剂，2)内分泌胰腺分化因子。
英文摘要
Functional inactivation of menin, encoded by the MEN1 gene, causes the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome and some but not all sporadic pancreatic endocrine tumors. Therefore exploring molecular events upstream or downstream of menin could point to other causative genes and/or regulatory events responsible for such tumor types. Our current efforts are directed towards studying 2 categories of genes for menin-regulated transcriptional, post-transcriptional, protein:protein interaction, and sub-cellular localization events: 1) Cyclin-dependent kinase inhibitors, and 2) Endocrine pancreas differentiation factors.
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