Immune modulatory effects of vaginal microbiota metabolites and HIV susceptibility

阴道微生物代谢物的免疫调节作用和 HIV 易感性

• 批准号: nhmrc : 1088564
• 负责人: Dr Anna Hearps
• 金额: $ 53.02万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-modulatory-effects-hiv-susceptibility/519221
• 关键词: Immune; modulatory; effects; vaginal; microbiota

This study will advance knowledge on how acid molecules produced by beneficial and harmful bacteria are able to promote or impede HIV infection of the female genital mucosa through their effects on the barrier and immune function of cells that line the vagina and cervix. The results of this study are anticipated to augment the efficacy of topical HIV prevention strategies and lead to the development of safe vaginal hygiene products that help protect against other sexually transmitted infections.

这项研究将推进关于有益和有害细菌产生的酸分子如何能够通过其对阴道和子宫颈细胞的屏障和免疫功能的影响来促进或阻止女性生殖器粘膜的HIV感染的知识。这项研究的结果预计将增加局部艾滋病毒预防策略的有效性，并导致开发安全的阴道卫生产品，有助于预防其他性传播感染。