MicroBrightField Bioscience Imaging System

MicroBrightField 生物科学成像系统

• 批准号: 7792965
• 负责人: Victor V Uteshev
• 金额: $ 18.98万
• 依托单位: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-20 至 2011-05-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792965
• 关键词: Address; Apoptosis; Cell physiology; Cells; Characteristics; Clinical Research; Faculty; Funding; Health Sciences; Illinois; Image; Internal Medicine; Kentucky; Link; Maps; Medical; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Natural regeneration; Operative Surgical Procedures; Pharmacology; Productivity; Property; Proteins; Request for Applications; Research; Research Personnel; Research Project Grants; Research Proposals; Source; System; Tennessee; United States National Institutes of Health; Universities; cellular development; improved; medical schools; member; morphometry; programs; reconstruction; research study

DESCRIPTION (provided by applicant): This application requests funds to purchase one Micro Bright Field (MBF) bioscience imaging system composed of two components: Neurolucida (http://www.mbfbioscience.com/neurolucida) and Stereo Investigator (http://www.mbfbioscience.com/stereo-investigator/stereo-investigator). The system will provide NIH-funded investigators at Southern Illinois University School of Medicine (SIU-SOM) Springfield, IL with the ability to conduct: 1) cellular reconstruction, 3D mapping and morphometry aimed at quantifying morphological characteristics of subsets of cells with specific properties (Neurolucida); and 2) stereological studies related to cellular development, apoptosis, survival, regeneration, function and expression of specific proteins (Stereo Investigator). These imaging capabilities are essential for analysis and characterization of morphological and cytochemical properties of cells as well as interconnectivity of subsets of cells and correlation of morphological and cytochemical properties with cellular functions and expression of specific proteins. At present, there is no imaging system with similar capabilities available at SIU-SOM and no similar imaging systems are available to SIU-SOM faculty members at neighboring universities. Several ongoing research projects either funded by the NIH or anticipated to be funded by the NIH in 2009 would be considerably improved by the availability of a MBF system at SIU-SOM. In the absence of MBF system, some SIU-SOM investigators (e.g., Dr. Uteshev) use their collaborative links to access MBF systems available at other universities (University of Tennessee Health Science Center, Memphis, TN; 381 miles away and University of Kentucky, Lexington, KY; 396 miles away). Other SIU investigators who do not have an access to MBF systems (e.g., Drs. Caspary and Rybak) have to truncate their research proposals to exclude experiments requiring usage of a MBF system. This proposal provides justification for the request of NIH funds to purchase one MBF system (Neurolucida and Stereo Investigator). The proposed purchase will greatly benefit basic medical and clinical research programs at SIU-SOM, will broaden the spectrum of scientific questions addressed by SIU investigators, and will increase the efficiency and productivity of SIU research. The participating investigators are faculty members of the Departments of Pharmacology, Internal Medicine and Surgery and are supported by the variety of sources of NIH funding (NIDDK, NIDCD, NIA, NINDS).

描述（由申请人提供）：此申请要求资金购买一个由两个组件组成的微型明亮领域（MBF）生物科学成像系统：Neurolucida（http://wwwww.mbfbioscience.com/neurololucida）和立体研究者（http://wwwwwwwwwwwwwwwwwwwww..mbfbicience.com/stererator/stererator/sterecore.com/stererator/sterecor）该系统将在伊利诺伊州南部伊利诺伊大学医学院（SIU-SOM）Springfield的NIH资助的研究人员提供行为能力：1）旨在量化具有特定特性（Neurololucida）细胞亚群形态特征的细胞重建，3D映射和形态计量学； 2）与细胞发育，凋亡，生存，再生，功能和表达有关特定蛋白质的立体学研究（立体研究者）。这些成像能力对于分析和表征细胞的形态和细胞化学特性以及细胞亚群的互连性以及形态和细胞化学特性与细胞功能以及特定蛋白质表达的相关性至关重要。 目前，还没有SIU-SOM可用的成像系统，并且邻近大学的SIU-SOM教职员工没有类似的成像系统。 NIH资助的一些正在进行的研究项目或预计将在2009年由NIH资助，将通过SIU-SOM的MBF系统的可用性可大大改善。在缺乏MBF系统的情况下，一些SIU-SOM研究人员（例如Uteshev博士）使用其协作链接来访问其他大学（田纳西大学健康科学中心，田纳西大学健康科学中心，田纳西州孟菲斯大学； 381英里外和肯塔基大学，肯塔基州，肯塔基州列克星顿市，肯塔基州； 396英里远）。其他无法访问MBF系统的SIU研究人员（例如Caspary和Rybak博士）必须截断其研究建议，以排除需要使用MBF系统的实验。该提案为NIH资金购买一个MBF系统（Neurolucida and Stereo调查员）的要求提供了理由。拟议的购买将极大地使SIU-SOM的基本医学和临床研究计划受益，将扩大SIU研究人员解决的科学问题的范围，并将提高SIU研究的效率和生产力。参与的研究人员是药理学，内科和手术部门的教职员工，并得到了NIH资金来源的支持（NIDDK，NIDCD，NIA，NINDS）。