Tim Upgrade for Nonhuman-Primate-Dedicated Magnetom Trio

蒂姆升级非人类灵长类专用磁力三重奏

• 批准号: 7792912
• 负责人: Christopher D Kroenke
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-13 至 2011-05-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792912
• 关键词: 7 year old; Algorithms; Award; Clinical Research; Computer software; Development; Equipment and supply inventories; Failure; Fatigue; Funding; Future; Generations; Health Sciences; Human; Image; Institution; Investigation; Knowledge; Lead; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Medical; Methodology; Microscopic; Operative Surgical Procedures; Oregon; Pathology; Physiologic Monitoring; Primates; Procedures; Process; Protocols documentation; Research; Research Project Grants; Research Subjects; Signal Transduction; Structure; System; Time; Tissues; Translational Research; Universities; base; clinical practice; computerized data processing; design; human subject; improved; instrument; instrumentation; nonhuman primate; public health relevance; repaired; research and development; research study; software systems; square foot; water diffusion

DESCRIPTION (provided by applicant: The Oregon National Primate Research Center (ONPRC) maintains a free-standing, 2,500 sq. ft. magnetic resonance imaging (MRI) facility that is within 100 ft. of the ONPRC surgical space, and is dedicated to the study of nonhuman primate subjects. This arrangement enables MRI-based investigations to be interfaced with virtually any ongoing research project at the ONPRC. Technical oversight of the ONPRC MRI facility is provided by the Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC). Through this cooperative endeavor, a number of nonhuman-primate-based MRI investigations are leading to the development of several new imaging strategies for monitoring physiological and anatomical processes that underlie primate pathology and development. Each of these experiments is potentially of direct translational value to current clinical research. At the time of award, the ONPRC Siemens MAGNETOM 3T Trio MRI system will be seven years old. Due to instrumentation fatigue over long-term use, system failures are becoming more frequent, and repair times are lengthier due to the manufacturer's smaller inventory of replacement parts for machines of this vintage. In this application, funds are being requested for a "Total imaging matrix" (Tim) upgrade to the ONPRC MRI system. Several recent technological developments in the ability to perform simultaneous acquisition of multiple receiver channels have stimulated MRI system manufacturers to substantially modify hardware designs. Current MRI systems differ from the ONPRC system by possessing more extensive "parallel imaging" capabilities. They can integrate a larger number signal input channels, and apply improved data processing algorithms to synthesize images. Additionally, improvements in gradient coil design have lead to the ability to more rapidly acquire images in dynamic experiments, and additionally improve measurements of water diffusion - a powerful methodology for characterizing tissue structure on the microscopic level. Within the context of the ONPRC/AIRC arrangement, an upgrade of the MRI system will greatly facilitate translational research by enabling sharing of protocols between the nonhuman primate MRI system and the AIRC's human Tim MRI systems located on the OHSU main campus (10 miles east of the ONPRC campus). Currently, image acquisition and processing procedures developed at OHSU and other research institutions system cannot be shared between systems due to inherent incompatibilities in software and hardware configurations of Tim and non-Tim instruments. As a result, most technological research and development occurs within the framework of Tim-generation systems. The requested funds will facilitate realization of the full translational potential of the ONPRC MRI system. PUBLIC HEALTH RELEVANCE: Funds are requested for the upgrade of an MRI system that is located on the Oregon National Primate Research Center (ONPRC) campus, and is dedicated to the study of nonhuman primate research subjects. Most nonhuman primate research focuses on the development of medical knowledge that can be used to direct future clinical practice. The requested upgrade will equip the ONPRC MRI system with improved hardware and software systems that will enable measurements performed on it to be identical to those performed on MRI systems used to examine human subjects.

描述（由申请人提供）：俄勒冈国家灵长类动物研究中心（ONPRC）拥有一个独立的，2500平方英尺。位于ONPRC手术空间100英尺范围内的磁共振成像（MRI）设备，专门用于非人类灵长类动物的研究。这种安排使得基于核磁共振的调查可以与ONPRC正在进行的几乎任何研究项目相结合。ONPRC核磁共振设备的技术监督由俄勒冈健康与科学大学（OHSU）高级成像研究中心（AIRC）提供。通过这一合作努力，一些基于非人类灵长类动物的MRI研究正在导致几种新的成像策略的发展，用于监测灵长类动物病理和发育背后的生理和解剖过程。这些实验中的每一个都有可能对当前的临床研究具有直接的转化价值。在授予时，ONPRC西门子MAGNETOM 3T Trio MRI系统将有7年的历史。由于仪器在长期使用中疲劳，系统故障变得越来越频繁，由于制造商对这款老式机器的更换零件库存较少，维修时间也更长。在此申请中，正在申请资金用于“总成像矩阵”（Tim）升级到ONPRC MRI系统。最近在同时采集多个接收器通道的能力方面的一些技术发展刺激了MRI系统制造商大幅修改硬件设计。目前的MRI系统与ONPRC系统的不同之处在于，它拥有更广泛的“并行成像”能力。它们可以集成更大数量的信号输入通道，并应用改进的数据处理算法来合成图像。此外，梯度线圈设计的改进已经导致在动态实验中更快地获取图像的能力，并且另外改进了水扩散的测量-一种在微观水平上表征组织结构的强大方法。在ONPRC/AIRC协议的背景下，核磁共振系统的升级将极大地促进转化研究，实现非人灵长类动物核磁共振系统和位于OHSU主校区（ONPRC校区以东10英里）的AIRC人类Tim核磁共振系统之间的协议共享。目前，由于Tim和非Tim仪器的软硬件配置固有的不兼容性，OHSU和其他研究机构系统开发的图像采集和处理程序无法在系统之间共享。因此，大多数技术研究和开发都是在tim生成系统的框架内进行的。所请求的资金将有助于实现ONPRC MRI系统的全部转化潜力。