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Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease

Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease
NADPH 氧化酶 1 衍生的 ROS 在帕金森病发病机制中的作用
批准号：
8220805
负责人：
YOON-SEONG KIM
金额：
$27.98万
依托单位：
UNIVERSITY OF CENTRAL FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-08-01 至 2013-06-30
来源：
https://reporter.nih.gov/project-details/8220805
关键词：
AffectAnimalsAutopsyBiologicalBrainCardiovascular systemCell DeathCellsComplexCytochrome P450DevelopmentDisease modelDopaminergic CellEnzymesEpidemiologyExperimental DesignsFamilyGenerationsGeneticGoalsGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesHomeostasisHomologous GeneHydrolysisImpairmentIn VitroInduced MutationInterventionKnock-outKnockout MiceLRRK2 geneLaboratoriesLeadLinkMAP Kinase Kinase KinaseMMP3 geneMediatingMemoryMitochondriaMolecularMultienzyme ComplexesMusMutationNADPNADPH OxidaseNerve DegenerationNeuraxisNeuronsNitric Oxide SynthaseOrganellesOrthologous GeneOxidasesOxidative StressOxidopamineParentsParkinson DiseasePathogenesisPathway interactionsPatientsPhagocytesPhasePhosphorylationPhosphotransferasesPhysiologicalPlayProductionProstaglandin-Endoperoxide SynthaseProtein IsoformsRattusReactionReactive Oxygen SpeciesRecombinantsReporterReportingRespiratory ChainRoleRotenoneSerumSignal TransductionSmall Interfering RNASourceStimulusSubstantia nigra structureSuperoxidesSystemTestingTetracyclinesTimeTissuesToxinTranscriptional ActivationTranscriptional RegulationTransgenic MiceTransgenic OrganismsVariantXanthine Oxidaseacetovanillonebasecytotoxicitydeprivationdopaminergic neuronin vivoinhibitor/antagonistleucine-rich repeat kinase 2mitochondrial dysfunctionmutantneuromelaninneuroprotectionnew therapeutic targetnigrostriatal dopaminergic pathwaynigrostriatal pathwayoverexpressionpars compactaperoxisomepreventpromoterprotein aggregationsmall hairpin RNA

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