Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease

NADPH 氧化酶 1 衍生的 ROS 在帕金森病发病机制中的作用

• 批准号: 8220805
• 负责人: YOON-SEONG KIM
• 金额: $ 27.98万
• 依托单位: UNIVERSITY OF CENTRAL FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8220805
• 关键词: Affect; Animals; Autopsy; Biological; Brain; Cardiovascular system; Cell Death; Cells; Complex; Cytochrome P450; Development; Disease model; Dopaminergic Cell; Enzymes; Epidemiology; Experimental Designs; Family; Generations; Genetic; Goals; Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Homeostasis; Homologous Gene; Hydrolysis; Impairment; In Vitro; Induced Mutation; Intervention; Knock-out; Knockout Mice; LRRK2 gene; Laboratories; Lead; Link; MAP Kinase Kinase Kinase; MMP3 gene; Mediating; Memory; Mitochondria; Molecular; Multienzyme Complexes; Mus; Mutation; NADP; NADPH Oxidase; Nerve Degeneration; Neuraxis; Neurons; Nitric Oxide Synthase; Organelles; Orthologous Gene; Oxidases; Oxidative Stress; Oxidopamine; Parents; Parkinson Disease; Pathogenesis; Pathway interactions; Patients; Phagocytes; Phase; Phosphorylation; Phosphotransferases; Physiological; Play; Production; Prostaglandin-Endoperoxide Synthase; Protein Isoforms; Rattus; Reaction; Reactive Oxygen Species; Recombinants; Reporter; Reporting; Respiratory Chain; Role; Rotenone; Serum; Signal Transduction; Small Interfering RNA; Source; Stimulus; Substantia nigra structure; Superoxides; System; Testing; Tetracyclines; Time; Tissues; Toxin; Transcriptional Activation; Transcriptional Regulation; Transgenic Mice; Transgenic Organisms; Variant; Xanthine Oxidase; acetovanillone; base; cytotoxicity; deprivation; dopaminergic neuron; in vivo; inhibitor/antagonist; leucine-rich repeat kinase 2; mitochondrial dysfunction; mutant; neuromelanin; neuroprotection; new therapeutic target; nigrostriatal dopaminergic pathway; nigrostriatal pathway; overexpression; pars compacta; peroxisome; prevent; promoter; protein aggregation; small hairpin RNA