Immuno-metabolic interactions of the fungal superbug Candida auris

感染威胁着医院的病人，并破坏了我们使用先进的医疗手段治疗癌症等疾病的能力。耳念珠菌是一种新兴的超级细菌，可引起医院和疗养院的感染，这些感染通常对一线抗真菌治疗有抵抗力。为了建立改进治疗的知识基础，该建议旨在定义C。奥里斯逃脱免疫防御和了解代谢机制，形状免疫反应和感染的结果。

Infections threaten hospital patients and undermine our ability to use advanced medical treatments for conditions such as cancer. Candida auris is an emerging superbug causing infections in hospitals and nursing homes that are commonly resistant to front-line antifungal therapy. To build the knowledge foundation for improved treatments, this proposal aims to define how C. auris escapes immune defences and understand the metabolic mechanisms that shape immune responses and infection outcomes.