NCCU NCMHD RESEARCH CENTER OF EXCELLENCE

描述（由申请人提供）：申请资金用于在北卡罗来纳中央大学建立ncccu nchd研究中心，重点研究少数民族健康差异。该中心将设在朱利叶斯L.钱伯斯生物医学/生物技术研究所，将包括行政、研究、研究教育/培训和社区参与/外展核心。行政核心将负责监督中心的所有项目、活动和预算。它将管理核心教师和研究/试点项目的选择，并协调所有伙伴关系安排的发展。研究核心将开展的项目的一个共同主题是，少数民族健康差异可能是复杂的基因-环境相互作用造成的。研究核心将支持两个完整的研究项目和两个试点项目：第一个研究项目旨在调查社会心理因素和易感基因多态性在促进非裔美国人对环境压力的生理血压反应和随后的高血压发展中的相互作用；第二个将寻求识别和表征与前列腺癌差异相关的遗传和表观遗传因素。试点项目为研究项目扩展和师资发展提供了独特的机会。三个共享资源设施将为研究和试点项目提供技术和后勤支助。研究教育/培训核心将监督高中、本科生、研究生、博士后助理和初级教师的实验室和课堂培训。它还将协助学术单位开发新的课程和学位课程。社区参与/外联核心将继续开展工作，制定向少数群体社区有效传播健康教育信息的方法。预期中大的少数族裔健康及健康差异研究中心将成为一个有价值、值得信赖的全院资源，以扩大中大进行少数族裔健康及健康差异研究的能力。

DESCRIPTION (provided by applicant): Funds are requested to develop an NCCU NCMHD Research Center at North Carolina Central University that focuses on minority health disparities. The Center will be housed in the Julius L. Chambers Biomedical/Biotechnology Research Institute and will comprise Administrative, Research, Research Education/Training, and Community Engagement/Outreach Cores. The Administrative Core will have oversight of all of the Center's programs, activities, and budgets. It will manage the selection of core faculty and research/pilot projects, and coordinate the development of all partnership arrangements. A common theme of projects that will be conducted by the research core is that minority health disparities may result from complex gene-environment interactions. The Research Core will support two full research projects and two pilot projects: the first research project is directed at investigating the interaction of psychosocial factors and susceptible genetic polymorphisms in contributing to the physiological blood pressure response to environmental stress and the subsequent development of hypertension in African Americans; and the second will seek to identify and characterize Genetic and Epigenetic Factors associated with Prostate Cancer Disparity. The pilot projects provide unique opportunities for research project expansion and faculty development. Three shared resources facilities will provide technical and logistical support for the research and pilot projects. The research education/training core will oversee laboratory and classroom training for high school, undergraduate, and graduate students, as well as post-doctoral associates and junior faculty. It will also assist the academic units with developing new curricula and degree programs. A Community Engagement/Outreach Core will continue its work on developing methods for effectively communicating health education messages to minority communities. It is anticipated that the NCCU NCMHD Research Center will become a valued, trusted, institution-wide resource for expanding NCCU's capacity to conduct minority health and health disparities research.