Immunodominance and protective immunity in the context of a complex host-pathogen system.

复杂宿主-病原体系统背景下的免疫优势和保护性免疫。

• 批准号: nhmrc : 1069466
• 负责人: Dr Nadine Dudek
• 金额: $ 60万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immunodominance-protective-immunity-pathogen-system/455395
• 关键词: Immunodominance; protective; immunity; context; complex

In experimental infection models with simple organisms, pathogen-specific immune responses recognize only a small fraction of potential epitopes encoded by the genome. This phenomenon is termed immunodominance. We propose the first comprehensive study of immunodominance in humans in response to a complex pathogen, the Plasmodium parasite that causes malaria. This will provide valuable new knowledge of host-pathogen immunity and facilitate rational vaccine design.

在简单生物体的实验感染模型中，病原体特异性免疫反应仅识别基因组编码的一小部分潜在表位。这种现象被称为免疫优势。我们提出了第一个全面的研究免疫优势在人类对一个复杂的病原体，疟原虫引起疟疾的反应。这将为宿主-病原体免疫提供有价值的新知识，并有助于合理设计疫苗。