Collaborative Observational Study of Myopia in COMET Children (COSMICC2)-UH

描述（由申请人提供）：本提案旨在休斯顿临床中心继续按照COSMICC 2方案每年对116名目前入组的COSMICC参与者（自97-98年入组以来，仅2名受试者退出）进行额外5年（总随访期，14年）的检查。从该中心收集的数据将用于解决主席赠款中更详细描述的具体目标，并简要总结为：1）使用数学函数（Gompers函数和其他），以模拟58%的COSMICC进展性近视受试者的近视进展，并基于先前确定的风险因素开发预测模型和检验假设（年龄、种族、父母近视）; 2）在这一特征明确的MOPE队列中检验与近视进展和稳定性以及眼轴延长的环境危险因素相关的4个假设;以及3）检验与COSMICC受试者中IOP、CCT和黄斑厚度的近视相关变化的发展的危险因素相关的三个假设。近视的高患病率（占美国成年人口的25%）及其作为公共卫生问题的突出地位 问题（可能导致视力丧失和失明的疾病的风险因素）强调了增加对进展和最终稳定的机制的理解的重要性，以便将来将近视限制在低水平。更好地了解预测近视进展和稳定的因素也将有助于指导干预措施的选择和时机，并针对那些可能从治疗中受益最多的群体。

DESCRIPTION (provided by applicant): This proposal is for the Houston Clinical Center to continue to annually examine the 116 currently enrolled COSMICC participants (only 2 subjects have withdrawn since recruited in 97-98) at the Houston center for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address specific aims described in more detail in the Chairman's grant and summarized briefly as :1)to use mathematical functions (the Gompers function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of mopes; and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health Problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.