Developmental Activities

发展活动

• 批准号: 7983702
• 负责人: ROBERT Samuel LANGER
• 金额: $ 8.25万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7983702
• 关键词: Advisory Committees; CCNE1 gene; Cells; Chad; Clinical; Collaborations; Communication; Communities; Consultations; DNA; Data; Databases; Deposition; Development; Direct Costs; Disseminated Malignant Neoplasm; Education and Outreach; Educational process of instructing; Evaluation; Exhibits; Faculty; Festival; Funding; General Population; Genes; Goals; Gold; Grant; Hybrids; Image; Magnetic Resonance Imaging; Mails; Microfluidics; Mission; Mus; Museums; Nanotechnology; Nucleic Acids; Pilot Projects; Public Domains; Publications; Research; Research Personnel; Research Project Grants; Resources; Schools; Science; Series; Sorting - Cell Movement; Staging; Students; Vision; Visit; Work; base; cancer Biomedical Informatics Grid; career; clinically relevant; data sharing; design; di-block copolymer; flexibility; high school; in vivo; interest; lectures; member; mouse model; nano; nanomaterials; nanomedicine; nanoparticle; neoplastic cell; outreach; programs; public education; tumor; web site

OVERALL VISION FOR DEVELOPMENTAL ACTIVITIES Over the last 5 years of our CCNE, there has been a tremendous interest by researchers to join the consortium through pilot projects and/or collaborative research. We view such projects as an important adjunct of the CCNE's mission and from which full projects and important science can emerge. For example, in the past our consortium has funded the selected following projects: ¿ Paula Hammond and Dane Wittrup (pilot project) on functionalized linear-dendritic diblock copolymers for tumor-selective nucleic acid delivery. One ofthe postdocs (Greg Thurber) now works in the Weissleder lab and confinues interactions (85, 86) ¿ Stephen Lippard (pilot project) on functionalizing gold nanoparticles with DNA duplexes containing tethered, releasable plafinum conjugates at their termini in collaboration with Chad Mirkin at Northwestern CCNE (87) ¿ Robert Westen/elt (pilot project) on hybrid integrated circuit/microfluidic chips forthe manipulation of cells (88, 89) ¿ Sridhar Ramaswamy (pilot project) on nanomodels of metastatic cancer (90) ¿ Mehmet Toner and Daniel Haber (pilot project) on microfluidic sorting of circulating tumor cells. This original pilot project has resulted in several high impact publications (91-93) and funding outside the consortium, including a recent SU2C grant involving several CCNE members (Bhatia, Weissleder). Pilot, Alliance Challenge and other exploratory projects provide a mechanism by which to attract new researchers and to rapidly fund the most promising ideas. The following section lists some of our general plans on continuing developmental activities.

发展活动的总体愿景 在我们CCNE的过去5年里，研究人员一直对通过试点项目和/或合作研究加入该联盟产生了极大的兴趣。我们认为这样的项目是CCNE使命的重要附属品，从中可以产生完整的项目和重要的科学。例如，我们的财团过去曾资助过以下选定的项目： Paula Hammond和Dane Wittrup(试点项目)研究用于肿瘤选择性核酸输送的功能化线状-树枝状两嵌段共聚物。其中一名博士后(格雷格·瑟伯饰)现在在韦斯莱德实验室工作，并限制互动(85，86) ？史蒂芬·利帕德(试点项目)用含有以下物质的DNA双链体使金纳米颗粒功能化 与乍得·米尔金合作，在其终点处捆绑、可释放的Plafinum连接物 CCNE西北部(87) ？Robert Westen/ELT(试点项目)关于混合集成电路/微流控芯片的操作 单元格(88，89) ？Sridhar Ramaswamy(转移性癌症纳米模型试点项目)(90) ？Mehmet Toner和Daniel Haber关于循环肿瘤细胞微流控分选的试点项目。这 最初的试点项目产生了几份影响很大的出版物(91-93)，并在 财团，包括最近涉及几个CCNE成员(Bhatia，Weissleder)的SU2C赠款。 试点、联盟挑战和其他探索性项目提供了一种机制，通过这种机制来吸引新的 并迅速为最有希望的想法提供资金。下一节列出了我们关于持续发展活动的一些总体计划。