EVASION OF ANTIGEN PRESENTATION BY RHESUS CYTOMEGALOVIRUS

恒河猴巨细胞病毒逃避抗原呈递

• 批准号: 8173206
• 负责人: Klaus J Fruh
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173206
• 关键词: Antigen Presentation; CD8B1 gene; Computer Retrieval of Information on Scientific Projects Database; Cytomegalovirus; Funding; Genes; Goals; Grant; Human; Immune; In Vitro; Institution; Macaca mulatta; Modeling; Molecular; Publishing; Research; Research Personnel; Resources; Role; Source; T-Lymphocyte; United States National Institutes of Health; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal is to identify and characterize cytomegaloviral immunomodulatory functions in vitro and to define their role for immune evasion in vivo. The goals of this application are a) to examine whether MHC I interference mechanisms are important for evading CD8+ T cell control in vivo using the rhesus CMV model in rhesus macaques, b) to examine the importance of MHC-I inhibitory genes related to human CMV or RhCMV-specific in vivo and c) to characterize the molecular mechanism of VIHCE, a RhCMV-specific MHC-I inhibitory genes. These aims have been accomplished and the results have been published.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的是确定和表征巨细胞病毒的免疫调节功能在体外，并确定其在体内免疫逃逸的作用。本申请的目的是a）使用恒河猴中的恒河猴CMV模型检查MHC I干扰机制对于逃避体内CD 8 + T细胞控制是否重要，B）检查体内与人CMV或RhCMV特异性相关的MHC-I抑制基因的重要性和c）表征VIHCE（一种RhCMV特异性MHC-I抑制基因）的分子机制。 这些目标已经实现，结果已经公布。