Sensory processing deficits in the schizophrenia prodrome

该项目代表了两种理论方法的创新集成，这两种方法具有巨大的潜力 改善对精神分裂症的预测并帮助阐明发病的神经机制 精神错乱。虽然青春期晚期/成年期早期是发病的典型时期，但很少有 前驱疾病的前瞻性研究主要集中在这一时期大脑功能的变化。 在发育的早期阶段，关于导致疾病的神经过程的信息可能 提高准确的预测，并可能导致针对特定异常的新干预措施 已确认身份。拟议的项目结合了两名资深调查人员的专业知识(康布拉特和 目前正在合作研究D-丝氨酸对SZ前驱症状的影响，并将 提供资金和资源，将贾维特博士的生物学方法引入康布拉特博士的 前瞻性、纵向前驱研究。康布拉特博士进行了一项关于识别 20多年来精神分裂症的神经认知、行为和临床危险因素自1998年以来，她一直 我是识别和预防(RAP)项目的负责人，该项目是一项针对青少年的前瞻性研究 Zucker Hillside有精神分裂症临床风险(即前驱症状)的12-22岁之间 医院(ZHH)。她将在这个项目中担任私人投资经理。该项目将纳入与活动相关的潜力 (事件相关电位)和感觉加工障碍的行为测量以增强现有的神经认知 电池。该项目的具体目标是1.引入一种感觉处理电池(行为 测量/ERP程序)到现有的RAP基线程序，并评估感官 缺陷存在于疾病的前驱阶段；2.评估感觉的短期变化 未服药的受试者与稳定服药的受试者在6个月时的加工和ERPs 药物治疗，以及3.评估与两年复测相关的处理过程的长期变化。我们有 选择对所有参与者进行为期两年的跟踪调查，因为之前的调查结果表明，在 这一时间段，可以预计在35%左右。对该项目的主要ERP支持将是 由核心B提供。将比较项目1、5和6的企业资源规划措施，以评估#年的赤字。 分别为慢性、前驱和首发队列。该项目还集成了数据库 项目6的组成部分，并将得到核心C的数据库和统计支持。 相关性(请参阅说明)： 精神分裂症是一种主要的精神障碍。神经认知功能障碍是 精神分裂症是长期预后不佳的主要决定因素。该项目是一个中心的一部分 应用于确定精神分裂症神经认知功能障碍的脑机制 特别强调感觉处理功能障碍。该项目将评估#年的赤字 精神分裂症症状异常患者的感觉加工 与其他项目和核心计划合作，作为改善早期发现和干预的一种方式。

This Project represents an innovative integration of two theoretical approaches that have great potential for improving prediction of schizophrenia and for helping to clarify the neural mechanisms involved in the onset of psychosis. Although late adolescence/eariy adulthood is the period when onset typically occurs, few prospective prodromal studies have focused on the changes in brain function that occur during this period. Information about the neural processes leading to illness during this eariy phase of development could both improve accurate prediction and potentially lead to novel interventions targeting the specific abnormalities identified. The proposed Project combines the expertise of two established investigators (Cornblatt and Javitt) who currently collaborate on studies of D-serine effects on symptoms in the SZ prodrome, and will provide the funding and resources to introduce Dr. Javitt's biological approach into Dr. Cornblatt's prospective, longitudinal prodromal study. Dr. Cornblatt has conducted research concerned with identifying neurocognitive, behavioral and clinical risk factors of schizophrenia for over 20 years. Since 1998, she has been the director of the Recognition and Prevention (RAP) program, a prospective study of adolescents between the ages of 12-22 who are at clinical risk (i.e., prodromal) for schizophrenia at Zucker Hillside Hospital (ZHH). She will serve as PI for this project. The project will incorporate event-related potential (ERP) and behavioral measures of sensory processing dysfunction to enhance existing neurocognitive batteries. Specific aims of the project are 1. to introduce a sensory processing battery (behavioral measures/ERP procedures) to the existing RAP baseline procedures and assess the extent to which sensory deficits are present in the prodromal stage of illness; 2. to evaluate short-term changes in sensory processing and ERPs at six months in subjects who are medication free as compared to those stabilized on medication, and 3. to assess long-term change in processing associated with a two-year retest. We have elected to follow all participants for two years, since previous findings indicate that conversions peak during this time period, and can be expected to be about 35%. Primary ERP support for this Project will be provided by Core B. ERP measures will be compared across Project 1, 5 and 6 to assess deficits in chronic, prodromal and first episode cohorts, respectively. This project integrates as well with database component of Project 6, and will receive database and statistical support from Core C. RELEVANCE (See instructions): Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This project is part of a Center application to determine brain mechanisms underiying neurocognitive dysfunction in schizophrenia with particular emphasis on sensory processing dysfunction. This project will evaluate deficits in sensory processing in patients showing prodi^omal symptoms of schizophrenia , in collaboration with other projects and core programs, as a way to improve eariy detection and intervention.