A Fluid-Structure Interaction Method for Patient-Specific Cardiovascular Modeling

描述（由申请人提供）：在过去的几年里，我们对涉及流固相互作用的生物过程的基本机制的理解有了巨大的进步。作为一个必要的合作伙伴，在数学建模、分析和模拟技术方面已经有了平行的发展，以解释这些机制。当这些方法与传统的MRI和CT扫描图像重建工具结合使用时，虽然这些方法有助于提高我们理解复杂过程（如血液流动与动脉壁的相互作用）的能力，但仍然非常需要高效的计算方法，不仅可以帮助定性地模拟生理现实情况，还可以帮助定量地分析和研究这些过程的三维患者特定建模。这些将是本提案的重点，并在大血管力学领域展示应用，特别是解决腹主动脉瘤破裂风险评估问题。本提案的主要目标是开发、实现、验证和应用一种有效的计算方法来分析多材料域的强耦合流固耦合（FSI）模型。该方法的应用将集中在原生AAAs瞬态生物力学环境的评估上。为了实现这一目标，我们提出了以下具体目标：(1)开发并验证一种高效、强耦合的流固耦合相互作用算法；(2)将FSI计算工具应用于针对患者的AAA临床研究，并评估相关动态血管力学的性能。

DESCRIPTION (provided by applicant): In the last few years, there have been dramatic advances in our understanding of fundamental mechanisms underlying biological processes involving fluid-structure interaction. As a necessary partner, there have been parallel developments in mathematical modeling, analysis and simulation techniques to explain these mechanisms. While these methods help enhance our ability to understand complex processes (such as the interaction of blood flow with the arterial wall) when used in conjunction with traditional MRI and CT scan image reconstruction tools, there is still a great need for efficient computational methods that can not only help simulate physiologically realistic situations qualitatively but also help analyze and study three-dimensional patient specific modeling of such processes quantitatively. These will be the focus of this proposal with a demonstrated application in the field of large blood vessel mechanics, specifically to address the issue of rupture risk assessment of abdominal aortic aneurysms. The primary goal of this proposal is to develop, implement, validate and apply an efficient computational methodology for analyzing strongly-coupled fluid-structure interaction (FSI) modeling for domains with multiple materials. The application of this methodology will be focused on the assessment of the transient biomechanical environment of native AAAs. The following specific aims are proposed to accomplish this goal: (1) Develop and validate an efficient, strongly-coupled fluid-structure interaction algorithm and (2) Apply the FSI computational tool to a patient-specific AAA clinical research study and evaluate the performance of the associated dynamic vascular mechanics. PUBLIC HEALTH RELEVANCE: This award will enable the development of a computational methodology for modeling the dynamic interaction between blood flow and the vessel wall at the organ scale. We will apply the method to non-invasively evaluate the biomechanical environment of abdominal aortic aneurysms (AAAs) dynamically. To this end, we will combine clinical imaging with computational algorithms to reconstruct patient-specific aneurysms and evaluate the flow-induced wall stresses and deformation. This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases.