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Protective Mechanisms of Statins in Alzheimer's Disease

Protective Mechanisms of Statins in Alzheimer's Disease
他汀类药物对阿尔茨海默病的保护机​​制
批准号：
8197438
负责人：
LING LI
金额：
$29.71万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-04-01 至 2013-03-31
来源：
https://reporter.nih.gov/project-details/8197438
关键词：
AdmixtureAffectAgeAlzheimer&aposs DiseaseAmericanAmyloidAmyloid beta-ProteinAmyloid depositionBehaviorBehavioralBiochemicalBlood - brain barrier anatomyBrainCardiovascular DiseasesCerebrumCholesterolClinical DataClinical TrialsCognitiveDataDementiaDevelopmentDietDiseaseDoseElderlyEventFunctional disorderGoalsGuidelinesHealthHeart DiseasesHippocampus (Brain)Impaired cognitionIn VitroInvestigationLeadLearningLifeLong-Term PotentiationMaintenanceMediatingMemoryMemory impairmentModificationMolecularMusNeurobiologyNeuronsNeurotransmitter ReceptorPathologyPathway interactionsPermeabilityPharmaceutical PreparationsPhosphorylationPlasmaPositioning AttributePrevalencePreventionProcessProductionPropertyProspective StudiesProtein BiosynthesisProtein PrecursorsReportingRetrospective StudiesSamplingSignal TransductionSignaling MoleculeSimvastatinSliceStagingSynapsesSynaptic plasticityTestingToxic effectTransgenic MiceVascular DiseasesWorkatorvastatinbasecholesterol biosynthesiscognitive functioncombatdesigneffective therapyexperiencefeedingin vivoinhibitor/antagonistinsightisoprenoidlipophilicitymevalonatemouse modelmutantnoveloverexpressionpresenilin-1preventprotective effectrosuvastatinsextrafficking

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  • 批准号：
    10645610
  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    UNIVERSITY OF MINNESOTA
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