IMMUNOPHILINS IN STEROID RECEPTOR- AND TISSUE-SPECIFIC ACTIONS: IMPLICATIONS FOR TREATMENT OF STEROID-BASED DISEASE

为了在细胞中转换类固醇激素信号，类固醇受体依赖于Hsp90分子伴侣机制，这对受体功能至关重要，特别是形成受体- Hsp90复合物的一部分的“辅助”伴侣，并微调受体对激素的反应。本研究探讨了受体辅助性伴侣亲环蛋白40的基本作用。我们的研究可能对类固醇性疾病的治疗有重要意义。

To convert steroid hormone signals in the cell steroid receptors rely on Hsp90 molecular chaperone machinery that is essential for receptor function and in particular 'helper' cohaperones that form part of receptor- Hsp90 complexes and fine-tune receptor responses to hormone. The present study addresses the fundamental role of the receptor helper' chaperone cyclophilin 40. Our study may have important implications for the treatment of steroid-based disease.