权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Olfactory Proteins in the Kidney and Regulation of Glomerular Filtration Rate

肾脏中的嗅觉蛋白与肾小球滤过率的调节

基本信息

批准号：
8103598
负责人：
Jennifer L Pluznick
金额：
$ 2.3万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-20 至 2011-05-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8103598
关键词：
Adenylate Cyclase Animals Anosmia Antibodies Appointment Bardet-Biedl Syndrome Binding Biological Assay Cells Chemicals Chronic Complement Custom Cystic kidney Data Detection Disease Distal Environment Exhibits Feedback Flow-It Functional disorder GTP-Binding Proteins Glomerular Filtration Rate Goals Homeostasis In Situ In Situ Hybridization In Vitro Individual Kidney Knock-out Knockout Mice Laboratories Length Ligands Macula densa Measures Micropuncture Molecular Monitor Mus Nephrons Nifedipine Nose Olfactory Epithelium Olfactory Pathways Oocytes Patients Phenotype Physiological Physiology Plasma Play Process Property Protein Isoforms Proteins Regulation Renal Tissue Renal function Renin Research Reverse Transcriptase Polymerase Chain Reaction Role Sensory Signal Pathway Signal Transduction Smell Perception Testing Tissues Universities Up-Regulation Urine Work Xenopus laevis arteriole base design in vitro Assay in vivo indexing interest laser capture microdissection novel olfactory receptor public health relevance receptor receptor binding receptor coupling research study response vasoconstriction

项目摘要

DESCRIPTION (provided by applicant): Olfactory receptors (ORs) are seven-transmembrane chemosensors which are responsible for the initial step of odorant detection in the olfactory epithelium. Recently, ORs have also been found to play a role in chemosensation in non-olfactory tissues. However, a role of ORs as chemosensors in the kidney, and therefore as potential regulators of kidney function, has not previously been investigated. Preliminary data demonstrates that individual ORs, as well as the necessary downstream signaling components of olfaction (the olfactory G protein and the olfactory form of adenylate cyclase) are expressed in the kidney. Furthermore, a mouse deficient for the olfactory form of adenylate cyclase is unable to properly regulate the rate of glomerular filtration - a deficit we believe is due to inappropriate regulation of tubuloglomerular feedback. In this proposal, we will: (1) Localize ORs within the kidney, (2) Determine if the olfaction machinery plays a role in tubuloglomerular feedback, and (3) Determine the ligand(s) detected by renal ORs in vitro and in vivo. The candidate's goals are focused on understanding renal physiology and pathophysiology, and she intends to pursue an academic appointment in research. The Department of Cellular and Molecular Physiology at Yale University is an ideal environment in which to further cultivate the candidate's interest and expertise in renal physiology, and the Sponsor's Laboratory provides an excellent setting in which to investigate a novel renal signaling pathway.

描述（由申请人提供）：