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A Global Screen for Genes Regulating Cdt1 Turnover In Response To DNA Damage

针对 DNA 损伤调节 Cdt1 更新的基因的全局筛选

基本信息

批准号：
8166000
负责人：
Malavika Raman
金额：
$ 5.47万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8166000
关键词：
26S proteasome ATP phosphohydrolase Ataxia-Telangiectasia-Mutated protein kinase Binding Cancer Biology Candidate Disease Gene Cataloging Catalogs Cell Cycle Cell Cycle Proteins Cell Cycle Regulation Cells Checkpoint kinase 1 Chromatin Chromosome abnormality Complex Cullin Proteins DNA DNA Binding DNA Damage DNA Repair DNA biosynthesis DNA lesion Ensure Enzymes Failure Fire - disasters G1 Phase Genes Genome Genomic Instability Genomics Genotoxic Stress Health Homeostasis In Vitro Lead Licensing Licensing Factor Ligase Link Mammalian Cell Membrane Microscopy Modeling Molecular Mutagens Mutation Organism Pathway interactions Phase Phosphotransferases Play Proteins Proteolysis Reaction Recruitment Activity Regulation Replication Initiation Replication Licensing Replication Origin Role S Phase Signal Pathway Signal Transduction Small Interfering RNA System Techniques Testing Transducers Ubiquitin Ubiquitination Work Xenopus base chromatin protein cofactor egg genetic regulatory protein genome wide association study genome-wide insight loss of function multicatalytic endopeptidase complex mutant novel prevent protein complex protein degradation receptor reconstitution response sensor tumorigenesis ubiquitin ligase ubiquitin-protein ligase

项目摘要

DESCRIPTION (provided by applicant): DNA replication is a crucial step in the cell cycle where cellular DNA must be faithfully copied only once. Failure to do so will result in either incomplete replication or multiple rounds of replication, both of which result in aberrant chromosome numbers. This proposal aims to understand how a protein known as Cdt1, which has been shown in all organisms to be the key player in controlling DNA replication, is regulated. Mis-regulation of Cdt1 levels plays a key role in tumorigenesis, underscoring the importance of this pathway in cancer biology.

描述(由申请人提供)：DNA复制是细胞周期中的关键步骤，细胞DNA必须忠实地复制一次。如果不这样做，将导致不完全复制或多轮复制，这两种情况都会导致染色体数量异常。这项提议旨在了解一种名为CDT1的蛋白质是如何受到调控的，这种蛋白质在所有生物体中都被证明是控制DNA复制的关键因素。CDT1水平的错误调节在肿瘤发生中起着关键作用，这突显了这一途径在癌症生物学中的重要性。