Determinants of Intra-abdominal Abscess Formation

腹内脓肿形成的决定因素

基本信息

  • 批准号:
    8111126
  • 负责人:
  • 金额:
    $ 5.68万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-01 至 2012-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The gram-negative anaerobe Bacteroides fragilis is an integral member of the mammalian gastrointestinal system. It is also the most frequently isolated organism from intra-abdominal abscesses, which generally arise from spillage of colonic contents and result in severe morbidity for patients. Previous work has demonstrated that the zwitterionic nature of the capsular polysaccharides found on B. fragilis is essential for abscess formation and that IL-17 is a critical component of the host immune response. The experiments outlined in this application seek to better understand the molecular underpinnings of intra-abdominal abscess formation by further exploring its determinants as related to both the innate immune system and commensal flora. In the first aim, we will identify the cellular and bacterial determinants of IL-17 production in B. fragilis infection. In the second aim, we will explore the role of the microbiota in intra-abdominal abscess formation. We hypothesize that gd T cells are a critical, early source of IL-17 required for abscess formation and that this production is influenced by specific commensal organisms. Taken together, these experiments will provide insight into the relationship between the microbiota, host immune function, and disease. Moreover, the proposed studies may provide novel therapeutic paradigms to treat and/or prevent bacterial infections. PUBLIC HEALTH RELEVANCE: The experiments outlined in this application study the immune mediators of a classic pathologic response to infection - abscess formation. These studies will broaden our understanding of the interplay between commensal organisms, abdominal infections, and the host immune response and has the potential to lead to novel paradigms to treat and/or prevent bacterial infections.
描述(由申请方提供):革兰氏阴性厌氧菌脆弱拟杆菌是哺乳动物胃肠道系统的组成成员。它也是腹腔内脓肿中最常见的分离微生物,腹腔内脓肿通常由结肠内容物溢出引起,并导致患者严重发病。以前的工作已经证明了在B上发现的荚膜多糖的两性离子性质。fragilis是脓肿形成所必需的,IL-17是宿主免疫应答的关键组分。本申请中概述的实验试图通过进一步探索与先天免疫系统和肠道植物群相关的决定因素来更好地理解腹腔内脓肿形成的分子基础。在第一个目标中,我们将鉴定B中IL-17产生的细胞和细菌决定因素。脆弱性感染。在第二个目标中,我们将探索微生物群在腹腔内脓肿形成中的作用。我们假设gd T细胞是脓肿形成所需的IL-17的一个关键的早期来源,并且这种产生受到特定的肠道微生物的影响。总之,这些实验将深入了解微生物群,宿主免疫功能和疾病之间的关系。此外,所提出的研究可能提供新的治疗范例来治疗和/或预防细菌感染。 公共卫生关系:本申请中概述的实验研究了感染-脓肿形成的经典病理反应的免疫介质。这些研究将拓宽我们对肠道微生物、腹部感染和宿主免疫反应之间相互作用的理解,并有可能导致治疗和/或预防细菌感染的新范例。

项目成果

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Neeraj K Surana其他文献

Neeraj K Surana的其他文献

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{{ truncateString('Neeraj K Surana', 18)}}的其他基金

Deconstructing how the microbiota influences the mucosal innate immune system
解构微生物群如何影响粘膜先天免疫系统
  • 批准号:
    8979668
  • 财政年份:
    2014
  • 资助金额:
    $ 5.68万
  • 项目类别:
Deconstructing how the microbiota influences the mucosal innate immune system
解构微生物群如何影响粘膜先天免疫系统
  • 批准号:
    8616538
  • 财政年份:
    2014
  • 资助金额:
    $ 5.68万
  • 项目类别:
Determinants of Intra-abdominal Abscess Formation
腹内脓肿形成的决定因素
  • 批准号:
    7999908
  • 财政年份:
    2010
  • 资助金额:
    $ 5.68万
  • 项目类别:

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  • 批准号:
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