CENTER OF EXCELLENCE IN DIABETES AND OBESITY RESEARCH: CORE E

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心赠款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 心血管成像和功能核心的作用是支持COBRE项目和相关研究，检查糖尿病和肥胖对心血管功能的影响。所提供的服务包括超声心动图成像、血压和心率的尾袖测量以及左心室（LV）压力-容积测量。目前，高容量超声心动图是使用飞利浦（HP）Sonos 5500机器进行的，该机器连接到配备回声分析软件的ComPACS计算机工作站。所有测量和计算数据均自动存储在ComPACS <$DE或SQL数据库中，采用DICOM SR格式，链接到Crystal Reports，用于生成自定义输出文档。用CODA-6尾套系统（肯特科技公司（Kent Scientific））对清醒小鼠的血压和心率进行非侵入性测量。使用Millar压力容积传导系统（MPCU-200）对小鼠进行主动脉和LV导管插入术。使用Chart（ADInstruments）获取血液动力学数据，并使用PVAN软件（Millar）分析以生成收缩和舒张指数。核心不仅为COBRE项目提供程序和技术支持，而且还扩展了新研究人员的能力，因为他们正在进行和未来的研究项目需要心血管成像。因此，核心方案促进了该方案支助的调查人员的职业发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The role of the Cardiovascular Imaging and Function Core is to support the COBRE Projects and related investigations examining the effects of diabetes and obesity on cardiovascular performance. The services provided include echocardiographic imaging, tail-cuff measurement of blood pressure and heart rate, and left ventricular (LV) pressure-volume measurement. High-volume echocardiography is currently performed with Philips (HP) Sonos 5500 machine coupled to a ComPACS Computer WorkStation complete with Echo Analysis Software. All measurements and computed data are automatically stored in ComPACS MSDE or SQL database in DICOM SR format linked to Crystal Reports for generating customized output documents. Non-invasive measurement of blood pressure and heart rate in conscious mice is performed with a CODA-6 tail-cuff system (Kent Scientific). Aortic and LV catheterization is performed using a Millar pressure volume conductance system (MPCU-200) for mice. Hemodynamic data are acquired using Chart (ADInstruments) and analyzed using PVAN software (Millar) to generate indexes of contraction and relaxation. The Core not only provides procedural and technological support for the COBRE Projects, but also extends the capabilities of new investigators as they embark on ongoing and future research projects requiring cardiovascular imaging. Thus, the Core advances the career development of COBRE-supported investigators.