Cognitive bases of schizophrenic language symptoms

精神分裂症语言症状的认知基础

• 批准号: 8025971
• 负责人: Nancy M. Docherty
• 金额: $ 28.68万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8025971
• 关键词: Area; Attention; Audiotape; Cereals; Cognitive; Communication; Concept Formation; Diagnostic Specificity; Disease; Failure; Functional disorder; Future; Goals; Image; Impaired cognition; Impairment; Intervention; Lead; Linguistics; Manic; Measures; Mind; Nature; Neurocognitive; Patients; Principal Investigator; Process; Quality of life; Rehabilitation therapy; Research; Sampling; Schizophrenia; Schizophrenic Language; Short-Term Memory; Specific qualifier value; Speech; Speech Disorders; Structure; Symptoms; Testing; Translating; base; cognitive function; disorder control; improved; programs; psychosocial; social; social cognition; theories; therapy design

DESCRIPTION (provided by applicant): This revised proposal is for continuation of an R01 project on schizophrenic disordered speech. Aims of the proposed project are to (1) confirm that impairments in basic neurocognitive processes are more highly associated with disordered speech when the speech disorder is measured from a communication perspective than when it is measured from a formal thought disorder or linguistic structural perspective; (2) replicate, extend, and refine findings on the unique and combined contributions of specific neurocognitive impairments to specific types of communication failures; (3) test the additional contributions of two social cognitive variables, relatedness and "theory of mind", to the communicative efficacy of patients' speech; (4) assess the degree to which each specific type of speech disorder is associated with deficits in social and vocational functioning; and (5) test for diagnostic specificity of the associations between the cognitive, social cognitive, and speech variables. We would assess multiple specified areas of cognitive, social cognitive, and social/ vocational functioning in 120 schizophrenia patients and 30 manic controls. We would collect speech samples from the same subjects, and analyze them for disorder of several different types. We would determine which types of speech disorder were most highly related to social/vocational dysfunction. We would examine the relationships between the neurocognitive and social cognitive measures, and assess their independent and shared contributions to the different types of speech disorder, controlling carefully for generalized deficit effects. This project could help to (a) identify which types of speech disorder are most disabling socially, and (b) further specify the abnormal processes underlying different forms of speech disorder. This would provide more specific, focused targets for imaging studies of speech symptoms. It also would have more immediate practical benefits: Disordered speech creates a substantial barrier to successful social and vocational functioning. A better understanding of its cognitive and social cognitive underpinnings could lead to the identification of specific, workable targets for pharmacological and psychosocial interventions designed to improve patients' communicative abilities and thereby improve their lives. Consideration would be given to ways of translating the findings of this study into workable interventions to improve patients' ability to communicate, which could be tested in future studies.

描述（由申请人提供）：此修订建议是为精神分裂症言语障碍的R 01项目的延续。该项目的目的是：（1）确认当言语障碍从交流的角度进行测量时，基本神经认知过程的损伤与言语障碍的相关性更高，而不是从形式思维障碍或语言结构的角度进行测量;（2）复制、扩展和完善关于特定神经认知障碍对特定类型沟通失败的独特和综合贡献的研究结果;（3）测试两个社会认知变量，关联性和“心理理论”，对患者言语交际效能的额外贡献;（4）评估每种特定类型的言语障碍与社会和职业功能缺陷的相关程度;（5）测试认知、社会认知和言语变量之间关联的诊断特异性。我们将评估120名精神分裂症患者和30名躁狂症对照者的认知、社会认知和社会/职业功能的多个特定领域。我们会从相同的受试者那里收集语音样本，并分析它们的几种不同类型的障碍。我们将确定哪些类型的言语障碍与社会/职业功能障碍最密切相关。我们将检查神经认知和社会认知测量之间的关系，并评估它们对不同类型言语障碍的独立和共同贡献，仔细控制广义缺陷效应。这个项目可以帮助（a）识别哪些类型的语言障碍最具社会残疾，（B）进一步说明不同形式的语言障碍的异常过程。这将为语言症状的成像研究提供更具体、更集中的目标。它也会有更直接的实际好处：言语障碍会对成功的社会和职业功能造成实质性障碍。更好地了解其认知和社会认知基础，可以导致确定具体的，可行的目标，旨在提高患者的沟通能力，从而改善他们的生活的药理学和心理社会干预。将考虑如何将这项研究的结果转化为可行的干预措施，以提高患者的沟通能力，这可以在未来的研究中进行测试。

项目成果

Schizotypy, alexithymia, and socioemotional outcomes.

• DOI: 10.1097/nmd.0b013e3182083bc4
• 发表时间: 2011-02
• 期刊: The Journal of nervous and mental disease
• 作者: Seghers JP;McCleery A;Docherty NM
• 通讯作者: Docherty NM

Internal versus external auditory hallucinations in schizophrenia: symptom and course correlates.

• DOI: 10.1080/13546805.2014.991387
• 发表时间: 2015
• 期刊: Cognitive neuropsychiatry
• 影响因子: 1.7
• 作者: Docherty NM;Dinzeo TJ;McCleery A;Bell EK;Shakeel MK;Moe A
• 通讯作者: Moe A

The cognitive origins of specific types of schizophrenic speech disturbances.

特定类型的精神分裂症言语障碍的认知起源。

• DOI: 10.1176/ajp.2006.163.12.2111
• 发表时间: 2006
• 期刊: The American journal of psychiatry
• 作者: Docherty,NancyM;Strauss,MiltonE;Dinzeo,ThomasJ;St-Hilaire,Annie
• 通讯作者: St-Hilaire,Annie

Reality monitoring and its association with social functioning in schizophrenia.

• DOI: 10.1016/j.psychres.2010.07.041
• 发表时间: 2011-03-30
• 期刊: PSYCHIATRY RESEARCH
• 影响因子: 11.3
• 作者: Divilbiss, Marielle;McCleery, Amanda;Aakre, Jennifer M.;Seghers, James P.;Schumann, Emily Bell;Docherty, Nancy M.
• 通讯作者: Docherty, Nancy M.

Confabulations in schizophrenia.

• DOI: 10.1080/13546805.2014.940886
• 发表时间: 2015
• 期刊: Cognitive neuropsychiatry
• 影响因子: 1.7
• 作者: Shakeel MK;Docherty NM
• 通讯作者: Docherty NM