Epistasis: its role in complex tratis, gene expression and speciation
上位性:其在复杂结构、基因表达和物种形成中的作用
基本信息
- 批准号:8032518
- 负责人:
- 金额:$ 42.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-05-01 至 2013-02-28
- 项目状态:已结题
- 来源:
- 关键词:AffectAfricaArchitectureAsiaAsiansAutistic DisorderBackBackcrossingsBehaviorBehavioralCessation of lifeCharacteristicsChromosome MappingChromosomesCodeCollectionComplement Factor HComplexCongenic StrainDNA SequenceDataDeformityDevelopmentDiabetes MellitusDrosophila genusEmbryoEnvironmentEvolutionExhibitsFertilityFlourGene CombinationsGene ExpressionGenesGeneticGenetic EpistasisGenetic MarkersGenetic ModelsGenetic TranscriptionGenomeGenomicsGenotypeGoalsHereditary DiseaseHomologous GeneHuman GeneticsHybridsIndividualInvestigationIslandLinkMalignant NeoplasmsMapsMeasuresMicrosatellite RepeatsModelingMolecularMolecular EvolutionMolecular GeneticsMotorNamesNorth AmericaObesityOrder ColeopteraParentsPatternPhenotypePlayPolymorphic Microsatellite MarkerPopulationPopulation GeneticsPredispositionPublishingQuantitative GeneticsRNA InterferenceRecombinantsResistanceRoleSchizophreniaSouth AmericaSouth AmericanStagingStructural GenesSurveysSystemTaxonTemperatureTestingTheoretical modelTriboliumbasebehavioral impairmentfitnessgene interactiongenome sequencinggenome-widememberneuromuscularoffspringpathogenreproductiveresearch studytheoriestrait
项目摘要
Our goal is to use theoretical models, gene expression arrays, molecular genetic markers
(SNPs and microsatellites) and molecular evolutionary theory to better understand how
gene interactions (epistasis) produce complex phenotypes. As our experimental system,
we will use recently collected populations of the red flour beetle, Tribolium castaneum,
which exhibit characteristics of incipient speciation in the form of inter-population
hybrids with impaired behavior, morphological deformities, and reduced fertility and
viability. Our specific aims include (1) confirming the functional identity of a pair of
genes from different populations that cause a total reduction of hybrid fitness when
brought together in a common genetic background; (2) characterizing the molecular
evolution of these genes through their patterns of expression and sequence diversity
within and among species; (3) identifying, confirming and characterizing a different set
of interacting genes which impair the motor behavior of inter-population hybrids; (4)
characterizing the differences in gene expression between inter-population hybrids and
their parents using Nimblegen¿ microarrays; and, (5) extending and testing two-locus
population genetic theory to a new model of speciation based on interactions between a
pair of genes, one with maternal and one with zygotic expression. Our extensive
preliminary studies, crossing pairs of populations from North and South America, Africa
and Asia, have revealed that dominance, epistasis, maternal genetic effects, and
genotype-by-environment interaction cause morphological and behavioral abnormalities
and reduced viability and fertility in inter-population hybrids. For the most extreme case
of hybrid fitness reduction, we have shown, through repeated back-crossing to the
genome strain, GA-2, and microsatellite marker mapping, that a specific pair of genes
interacts to reduce hybrid fitness. We have also shown that inter-population behavioral
abnormalities occur in matings and backcrosses between a different pair of populations;
that they are not caused one of the genes responsible for the extreme reduction of hybrid
fitness (above); and that they involve the breakdown of linked gene combinations. By
continuing our back-crosses to the genomic strain, we can isolate the gene combinations
causing the behavioral abnormalities in a common genetic background, confirm their
functional identity, and characterize their evolution within and among species.
我们的目标是利用理论模型,基因表达阵列,分子遗传标记
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Jeffery Demuth其他文献
Jeffery Demuth的其他文献
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{{ truncateString('Jeffery Demuth', 18)}}的其他基金
Epistasis: its role in complex tratis, gene expression and speciation
上位性:其在复杂结构、基因表达和物种形成中的作用
- 批准号:
8030748 - 财政年份:2010
- 资助金额:
$ 42.88万 - 项目类别:
Epistasis: its role in complex tratis, gene expression and speciation
上位性:其在复杂结构、基因表达和物种形成中的作用
- 批准号:
7655864 - 财政年份:2003
- 资助金额:
$ 42.88万 - 项目类别:
Epistasis: its role in complex tratis, gene expression and speciation
上位性:其在复杂结构、基因表达和物种形成中的作用
- 批准号:
8235919 - 财政年份:2003
- 资助金额:
$ 42.88万 - 项目类别:
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