Cell Biology and Signaling

癌细胞生物学和信号程序 癌细胞生物学和信号传递计划由来自6个国家的19名研究人员组成 各部门。该计划的任务是阐明细胞信号在调节细胞生长中的作用， 分化和细胞凋亡。该计划侧重于三个主要研究领域：1)了解 参与调节细胞生长和分化的分子机制，重点是 酪氨酸激酶和G蛋白偶联受体信号通路的作用；2)阐明分子 调节细胞凋亡的机制；以及3)细胞外基质在调节中的作用 细胞的生长和迁移。 该计划的一个重要科学目标是整合对 通过KCC的翻译研究工作，调节细胞的生长、分化和凋亡。这 应该有助于更好地理解癌症的生物学，也有助于基础研究的转化 转化为治疗癌症的新治疗策略。所有计划成员都是由美国国立卫生研究院资助的。他们 目前有260万美元的NCI支持和980万美元的同行审查支持。计划 成员共发表320篇癌症相关稿件(8%为计划内稿件，13%为计划间稿件) 在最后一次授权期内。

CANCER CELL BIOLOGY AND SIGNALING PROGRAM The Cancer Cell Biology and Signaling Program is comprised of nineteen investigators from six departments. The program mission is to elucidate the role of cell signaling in regulating cell growth, differentiation, and apoptosis. The program focuses on three major areas of research: 1) understanding the molecular mechanisms involved in the regulation of cell growth and differentiation with an emphasis on the role of tyrosine kinase and G protein-coupled receptor signaling pathways; 2) elucidating the molecular mechanisms regulating cell apoptosis; and 3) addressing the role of the extracellular matrix in regulating cell growth and migration. An important scientific goal of this program is to integrate fundamental studies on the mechanisms that regulate cell growth, differentiation, and apoptosis with the translational research efforts at the KCC. This should result in a better understanding of the biology of cancer and also in the translation of basic research into novel therapeutic strategies for the treatment of cancer. All program members are NIH funded. They currently have $2.6 million of NCI support and $9.8 million of total, peer-reviewed support. Program members published a total of 320 cancer-relevant manuscripts (8% intra-programmatic and 13% interprogrammatic) during the last grant period.