MOLECULAR CHARACTERIZATION OF THE BOCAVIRUSES

博卡病毒的分子特征

• 批准号: 8168400
• 负责人: Jianming Qiu
• 金额: $ 10.83万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168400
• 关键词: Accounting; Animals; Canis familiaris; Cell Death; Cells; Child; Computer Retrieval of Information on Scientific Projects Database; Epidemiology; Funding; Grant; Human; Infection; Institution; Lower Respiratory Tract Infection; Molecular; Outcome Measure; Parvovirinae; Proteins; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Viral; Virus; base; bovine parvovirus; human DNA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Bocavirus is a newly defined genus of subfamily Parvovirinae, which includes bovine parvovirus (BPV), minute virus of canine (MVC) and the recently identified human bocavirus (HBoV). HBoV has been associated with lower respiratory tract infections in children, and has been suggested to account for as much as 5% of lower respiratory tract infections worldwide. Rational: Currently, both virus and infectious DNA of HBoV are not available, characterization of the animal bocavirus MVC will eventually provide information to the genus Bocavirus in general. Study question: Understanding the epidemiology of HBoV infection in humans and the molecular basis how bocaviruses replicate in host cells. Outcome measures: construct infectious clone of bocaviruses to dissect the roles of bocavirus proteins in viral replication and understand the mechanism underlying bocavirus infection induces cell death of infected cells.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 背景：Bocavirus是帕维维那亚家族的新定义的属，其中包括牛蓝菜病毒（BPV），犬类的微小病毒（MVC）和最近确定的人类Bocavirus（HBOV）。 HBOV与儿童的下呼吸道感染有关，并被建议占全球下呼吸道感染的5％。 理性：目前，HBOV的病毒和感染性DNA都无法使用，动物Bocavirus MVC的表征最终将为Bocavirus属提供信息。 研究问题：了解人类HBOV感染的流行病学以及分子基础如何在宿主细胞中复制。结果度量：构建Bocaviruses的传染性克隆，以剖析Bocavirus蛋白在病毒复制中的作用，并了解Bocavirus感染的机制会导致感染细胞的细胞死亡。