DEVELOPMENT OF METABOLIC SYNDROME IN FILIPINO, NATIVE HAWAIIAN AND SAMOAN YOUTH

肥胖症流行率最近急剧增加，紧随其后的是迅速上升的 代谢并发症，特别是糖尿病和代谢综合征的患病率，是公认的， 但对涉及脂质、葡萄糖和激素失调的疾病知之甚少， 增加心血管疾病的风险。MS的患病率在成年人中显著增加 在过去的20年里，23.7%。更令人担忧的是，在1999年的NHANES中，超过30%的超重青少年- 2000年的调查发现有MS表型。 肥胖和糖尿病在某些种族群体中很常见，包括亚洲人、夏威夷土著人和 太平洋岛民（PI）多发性硬化症在包括NH和亚洲人在内的某些种族群体中也更常见 成年人，尤其是菲律宾人。菲律宾、NH和其他PI儿童的肥胖率很高， MS的患病率尚不清楚。鉴于儿童肥胖和成人MS的高患病率，菲律宾人， NH和其他PI儿童可能特别容易患MS。 看似MS的生理异常最初可能是可逆的，但后来变得稳定， 这种可逆性强调了这样一种观点，即为了了解MS， 制定有效的预防和治疗方案，我们需要了解它在儿童时期是如何发展的， 特别是在不同的高风险人群中，如亚洲人和PI。 本研究的具体目的是：1）确定MS在高危人群中的患病率， 超重的菲律宾人，NH和萨摩亚青少年2）检查身体和实验室的模式 3）为了检测MS的发生与MS的发生之间的关系， 妊娠和儿童早期因素与MS发展之间的关系 这项研究将是一项以社区为基础的横断面研究，涉及450名菲律宾人、新罕布什尔州人和萨摩亚人。 从夏威夷及周边地区的社区健康中心招募的超重和高危青少年 社区团体。受试者将接受人体测量、身体成分分析和 实验室研究，以确定哪些超重的青少年有MS表型。医疗记录将 审查以收集妊娠、儿童生长数据并确定与MS发展的相关性。 公众：代谢综合征（MS）是一种常见的和严重的后果，肥胖涉及的问题 调节血脂、血糖和血压，增加患心血管疾病的风险。 像肥胖一样，它在儿童中变得越来越普遍，但对其如何发展知之甚少。本研究将 确定MS在高风险、未充分研究的亚洲和太平洋岛屿儿童人群中的常见程度 并研究妊娠和幼儿期因素与MS发病的关系。

The recent and dramatic increase in the obesity prevalence has been followed closely by a rapidly rising prevalence of metabolic complications, especially diabetes and the metabolic syndrome, a well recognized, but poorly understood condition involving lipid, glucose and hormonal dysregulation associated with increased risk for cardiovascular disease. The prevalence of MS has increased significantly among adults over the last 20 years to 23.7%. More worrisome, over 30% of overweight adolescents in the NHANES 1999- 2000 survey were found to have a MS phenotype. Obesity and diabetes are common among certain ethnic groups including Asians, Native Hawaiians and other Pacific Islanders (PI). MS is also more common among certain ethnic groups including NH and Asians adults, especially Filipinos. Filipino, NH and other PI children have a high prevalence of obesity but prevalence of MS is not known. In light of the high prevalence of childhood obesity and adult MS, Filipino, NH and other PI children may be particularly susceptible to the development of MS. Physiologic abnormalities that appear to be MS may be reversible initially but become stable later and much more difficult to treat. This reversibility underscores the idea that in order to understand MS, and develop effective prevention and treatment programs, we need to understand how it develops in childhood, especially in diverse, high-risk populations such as Asian and PI. The specific aims of this study are to 1) To determine the prevalence of MS in a high-risk population of overweight Filipino, NH, and Samoan adolescents 2) To examine the pattern of physical and laboratory markers associated with the development MS in a high-risk population of children 3) To examine the relationship between gestational and early childhood factors and the development of MS/ The study will be a cross-sectional community-based study of 450 Filipino, NH and Samoan overweight and at risk for overweight youth recruited from community health centers in Hawaii and surrounding community groups. Subjects will undergo anthropometric measurement, body composition analysis and laboratory studies to determine which overweight adolescents have a MS phenotype. Medical records will be reviewed to collect pregnancy, child growth data and determine associations with the development of MS. PUBLIC: Metabolic syndrome (MS) is a common and serious consequence of obesity involving problems with lipid, glucose and blood pressure regulation and increases risk of developing cardiovascular disease. Like obesity, it is becoming more common in children but little is known about how it develops. This study will determine how common MS is in a population of high-risk, understudied Asian and Pacific Island children and examine the relationship between factors in pregnancy and early childhood and the onset of MS.