DEVELOPMENT OF METABOLIC SYNDROME IN FILIPINO, NATIVE HAWAIIAN AND SAMOAN YOUTH

最近肥胖症患病率急剧上升，紧随其后的是迅速上升的 代谢并发症的流行，特别是糖尿病和代谢综合征，这是公认的， 但人们对涉及血脂、血糖和激素失调的疾病知之甚少 增加患心血管疾病的风险。多发性硬化症在成人中的患病率显著增加 在过去的20年里下降到23.7%。更令人担忧的是，在NHANES 1999年中，超过30%的超重青少年- 2000年调查发现具有MS表型。 肥胖和糖尿病在某些种族群体中很常见，包括亚洲人、夏威夷原住民和 其他太平洋岛民(PI)。多发性硬化症在某些民族中也更常见，包括NH人和亚洲人 成年人，尤其是菲律宾人。菲律宾、NH和其他PI儿童肥胖率很高，但 多发性硬化症的患病率尚不清楚。鉴于儿童肥胖症和成人多发性硬化症的高流行率，菲律宾人， NH和其他PI儿童可能特别容易患上MS。 看似多发性硬化症的生理异常最初可能是可逆的，但后来变得稳定 治疗起来要困难得多。这种可逆性强调了这样一种观点，即为了理解多发性硬化症， 制定有效的预防和治疗方案，我们需要了解它在儿童时期是如何发展的， 特别是在不同的高危人群中，如亚洲人和少年派。 这项研究的具体目的是1)确定多发性硬化症在高危人群中的患病率 超重的菲律宾、NH和萨摩亚青少年2)检查身体和实验室的模式 在儿童高危人群中检测与多发性硬化症发育相关的标记物 妊娠和儿童早期因素与多发性硬化发病的关系 这项研究将是一项基于社区的横断面研究，涉及450名菲律宾人、NH人和萨摩亚人的超重 从夏威夷及其周边地区的社区卫生中心招募的超重青年面临风险 社区团体。受试者将接受人体测量、身体成分分析和 实验室研究以确定哪些超重青少年具有多发性硬化症表型。医疗记录将会是 审查以收集怀孕和儿童生长数据，并确定与多发性硬化发展的关系。 公众：代谢综合征(MS)是肥胖的一种常见和严重的后果，涉及各种问题 与调节血脂、血糖和血压有关，并增加患心血管疾病的风险。 像肥胖一样，它在儿童中变得越来越常见，但人们对它的发展过程知之甚少。这项研究将 确定多发性硬化症在高危、研究不足的亚洲和太平洋岛屿儿童群体中的患病率 并研究孕期因素和儿童早期因素与MS发病的关系。

The recent and dramatic increase in the obesity prevalence has been followed closely by a rapidly rising prevalence of metabolic complications, especially diabetes and the metabolic syndrome, a well recognized, but poorly understood condition involving lipid, glucose and hormonal dysregulation associated with increased risk for cardiovascular disease. The prevalence of MS has increased significantly among adults over the last 20 years to 23.7%. More worrisome, over 30% of overweight adolescents in the NHANES 1999- 2000 survey were found to have a MS phenotype. Obesity and diabetes are common among certain ethnic groups including Asians, Native Hawaiians and other Pacific Islanders (PI). MS is also more common among certain ethnic groups including NH and Asians adults, especially Filipinos. Filipino, NH and other PI children have a high prevalence of obesity but prevalence of MS is not known. In light of the high prevalence of childhood obesity and adult MS, Filipino, NH and other PI children may be particularly susceptible to the development of MS. Physiologic abnormalities that appear to be MS may be reversible initially but become stable later and much more difficult to treat. This reversibility underscores the idea that in order to understand MS, and develop effective prevention and treatment programs, we need to understand how it develops in childhood, especially in diverse, high-risk populations such as Asian and PI. The specific aims of this study are to 1) To determine the prevalence of MS in a high-risk population of overweight Filipino, NH, and Samoan adolescents 2) To examine the pattern of physical and laboratory markers associated with the development MS in a high-risk population of children 3) To examine the relationship between gestational and early childhood factors and the development of MS/ The study will be a cross-sectional community-based study of 450 Filipino, NH and Samoan overweight and at risk for overweight youth recruited from community health centers in Hawaii and surrounding community groups. Subjects will undergo anthropometric measurement, body composition analysis and laboratory studies to determine which overweight adolescents have a MS phenotype. Medical records will be reviewed to collect pregnancy, child growth data and determine associations with the development of MS. PUBLIC: Metabolic syndrome (MS) is a common and serious consequence of obesity involving problems with lipid, glucose and blood pressure regulation and increases risk of developing cardiovascular disease. Like obesity, it is becoming more common in children but little is known about how it develops. This study will determine how common MS is in a population of high-risk, understudied Asian and Pacific Island children and examine the relationship between factors in pregnancy and early childhood and the onset of MS.