女性外用活杀微生物剂的开发-猫眼课题宝

女性外用活杀微生物剂的开发

批准号：

8126267

负责人：

Laurel A. Lagenaur

金额：

$36.45万

依托单位：

OSEL, INC.

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-09-30 至 2013-08-31

来源：

https://reporter.nih.gov/project-details/8126267

关键词：

Address Adherence Animals Antibiotic Resistance Antibiotics Bacteria Bacterial Vaginosis Biological Markers Biological Products Biomedical Engineering Cell Line Cervical Chinese People Chromosomes Coculture Techniques Collection Consultations Cyanovirin-N Development Dose Drug Evaluation Drug Formulations Epidemiologic Studies Epithelial Cells Epithelium Evaluation Research Female Generations Genetic Genetically Modified Organisms Genital system Genome Stability HIV HIV Entry Inhibitors HIV-1 Heterosexuals Human Human Volunteers Hydrogen Hydrogen Peroxide Immune In Situ Infection Investigational Drugs Investigational New Drug Application Lactobacillus Lead Life Local Microbicides Macaca mulatta Modeling Opportunistic Infections Organism Pharmacologic Substance Phase Phase II Clinical Trials Proteins Recombinants Recurrence Risk Safety Seminal Plasma Sexually Transmitted Diseases Therapeutic Transference United States Dept. of Health and Human Services Urinary tract infection Vagina Viral Woman Work base design immunogenicity immunotoxicity manufacturing process microbicide nonhuman primate novel pathogen pre-clinical preclinical efficacy preclinical safety preclinical study prevent self-renewal simian human immunodeficiency virus transmission process vaginal lactobacilli volunteer

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英文摘要

This proposal outlines the development of a novel live microbicide, termed MucoCept, designed to prevent heterosexual HIV transmission in women. MucoCept is an H2O2- producing vaginal L. jensenii 1153 strain that has been genetically modified to constitutively secrete a potent anti-HIV protein, cyanovirin-N (CV-N). We propose to assess the safety, tolerability and affect on innate genital tract immune factor and colonization following application of a CV-N expressing L. jensenii designated 1153- 1666 using the Non-Human Primate model. In addition, we will assess and confirm the clearance of the L. jensenii 1153-1666 strain in the Non-Human primate following antibiotic administration.

期刊论文(4)

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科研奖励(0)

会议论文

Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women.

DOI： 10.1371/journal.pone.0122730

发表时间： 2015

期刊：

PloS one

影响因子： 3.7

作者：

[Lagenaur LA, Swedek I, Lee PP, Parks TP]