Advanced Pacing Methods for Treating Heart Rhythm Disturbances
治疗心律紊乱的先进起搏方法
基本信息
- 批准号:8118799
- 负责人:
- 金额:$ 16.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAlgorithmsAnimal ModelApplications GrantsArrhythmiaBody SurfaceCardiacChestChronicCoronary sinus structureCoupledDetectionDevelopmentDevicesEventFailureFamily suidaeGoalsGrowthHeartHeart failureHospitalsImplantable DefibrillatorsLeadLeftLeft ventricular structureLifeMeasuresMethodsMorbidity - disease rateMorphologyMyocardial InfarctionPatientsPatternPhysiologic pulsePredispositionPreventivePrior TherapyQuality of lifeResearch ProposalsRight ventricular structureSeriesShapesShockSignal TransductionSiteSystemTachyarrhythmiasTechnologyTimeUpdateVariantVentricularVentricular ArrhythmiaVentricular FibrillationVentricular Tachycardiabasedesignheart electrical activityheart rhythmhemodynamicsimprovedmortalitynew technologynext generationnovelpreventpublic health relevancesudden cardiac deaththerapy design
项目摘要
DESCRIPTION (provided by applicant): The implantable cardioverter defibrillator (ICD) is the most effective means of detecting and treating arrhythmias, such as ventricular tachycardia (VT) or ventricular fibrillation (VF). However, despite its rapid acceptance, the main limitation of the current ICD technology is that it aims to terminate an arrhythmia only after the arrhythmia has started. Given that failure, delay or false detection in detecting VT/VF is a life- threatening concern, it is imperative that the next generation of ICD technology is able to prevent arrhythmias from starting rather than terminating them after their initiation. Electrical alternans is a pattern of variation in the shape of electrocardiographic waveform that appears on an every other beat basis. Alternation in ventricular repolarization, namely repolarization alternans (RA), has been associated with increased vulnerability to VT/VF and sudden cardiac death (SCD) in patients with heart failure. Thus, in this R21 grant application, we propose to investigate the hypothesis that therapy application by an ICD before the abnormal heart rhythm develops will provide a significant improvement not only in preventing SCD but also in patient acceptance of ICD therapy and quality of life. We have developed a system that can both estimate RA in real- time from intracardiac electrograms and deliver electrical pulses that are timely coupled to the cardiac electrical activity. In this proposal we will investigate the applicability of RA-triggered delivery of clinically appropriate electrical therapy to suppress/terminate RA and prevent the development of VT/VF in an animal model of chronic myocardial infarction. To achieve the aims of this proposal we will (i) establish criteria for the detection of statistically significant RA preceding the onset of a tachyarrhythmic event in a swine animal model, (ii) develop effective algorithms to trigger electrical therapy and investigate the efficacy of electrical therapy in reducing/suppressing the level of RA preceding the onset of a tachyarrhythmic event.
PUBLIC HEALTH RELEVANCE: The implantable cardioverter defibrillator (ICD) is a device that detects arrhythmias, such as VT or VF, and terminates them by delivery of one or more electrical impulses to the heart. However, failure, delay or false detection in detecting VT or VF are of great concern. This research proposal investigates the application of therapy by an ICD before the abnormal heart rhythm develops, thus providing a significant improvement not only in preventing sudden cardiac death but also in patient acceptance of ICD therapy and quality of life.
描述(由申请人提供):植入式心脏复律除颤器(ICD)是检测和治疗心律失常(例如室性心动过速(VT)或心室颤动(VF))的最有效手段。然而,尽管其迅速被接受,当前ICD技术的主要限制是它的目的是仅在心律失常开始后终止心律失常。鉴于检测 VT/VF 的失败、延迟或错误检测会危及生命,因此下一代 ICD 技术必须能够防止心律失常发生,而不是在心律失常发生后终止它们。电交替是心电图波形形状的一种变化模式,每隔一个心跳出现一次。心室复极交替,即复极交替 (RA),与心力衰竭患者发生 VT/VF 和心源性猝死 (SCD) 的可能性增加有关。因此,在本次 R21 拨款申请中,我们建议研究这样的假设:在出现异常心律之前应用 ICD 治疗不仅可以显着改善预防 SCD,而且可以显着改善患者对 ICD 治疗的接受度和生活质量。我们开发了一种系统,既可以根据心内电图实时估计 RA,又可以提供与心电活动及时耦合的电脉冲。在本提案中,我们将研究 RA 触发的临床适当电疗法在慢性心肌梗死动物模型中抑制/终止 RA 并预防 VT/VF 发展的适用性。为了实现本提案的目标,我们将 (i) 建立在猪动物模型中快速心律失常事件发作前统计显着 RA 的检测标准,(ii) 开发有效的算法来触发电疗并研究电疗在降低/抑制快速心律失常事件发作前的 RA 水平方面的功效。
公共健康相关性:植入式心律转复除颤器 (ICD) 是一种检测心律失常(例如 VT 或 VF)并通过向心脏传送一个或多个电脉冲来终止心律失常的设备。然而,检测 VT 或 VF 时的失败、延迟或错误检测令人非常担忧。该研究计划调查了在心律异常发生之前应用 ICD 治疗,从而不仅可以显着改善预防心源性猝死,还可以提高患者对 ICD 治疗的接受度和生活质量。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
T-wave alternans as an arrhythmic risk stratifier: state of the art.
- DOI:10.1007/s11886-013-0398-7
- 发表时间:2013-09
- 期刊:
- 影响因子:3.7
- 作者:Merchant, Faisal M.;Sayadi, Omid;Moazzami, Kasra;Puppala, Dheeraj;Armoundas, Antonis A.
- 通讯作者:Armoundas, Antonis A.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ANTONIS A ARMOUNDAS其他文献
ANTONIS A ARMOUNDAS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ANTONIS A ARMOUNDAS', 18)}}的其他基金
Method for guiding ablative therapy of cardiac arrythmias
指导心律失常消融治疗的方法
- 批准号:
8121394 - 财政年份:2010
- 资助金额:
$ 16.46万 - 项目类别:
Method for guiding ablative therapy of cardiac arrythmias
指导心律失常消融治疗的方法
- 批准号:
8289598 - 财政年份:2010
- 资助金额:
$ 16.46万 - 项目类别:
Method for guiding ablative therapy of cardiac arrythmias
指导心律失常消融治疗的方法
- 批准号:
7946087 - 财政年份:2010
- 资助金额:
$ 16.46万 - 项目类别:
Method for guiding ablative therapy of cardiac arrythmias
指导心律失常消融治疗的方法
- 批准号:
8470224 - 财政年份:2010
- 资助金额:
$ 16.46万 - 项目类别:
Advanced Pacing Methods for Treating Heart Rhythm Disturbances
治疗心律紊乱的先进起搏方法
- 批准号:
7990595 - 财政年份:2010
- 资助金额:
$ 16.46万 - 项目类别:
相似海外基金
DMS-EPSRC: Asymptotic Analysis of Online Training Algorithms in Machine Learning: Recurrent, Graphical, and Deep Neural Networks
DMS-EPSRC:机器学习中在线训练算法的渐近分析:循环、图形和深度神经网络
- 批准号:
EP/Y029089/1 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Research Grant
CAREER: Blessing of Nonconvexity in Machine Learning - Landscape Analysis and Efficient Algorithms
职业:机器学习中非凸性的祝福 - 景观分析和高效算法
- 批准号:
2337776 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Continuing Grant
CAREER: From Dynamic Algorithms to Fast Optimization and Back
职业:从动态算法到快速优化并返回
- 批准号:
2338816 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Continuing Grant
CAREER: Structured Minimax Optimization: Theory, Algorithms, and Applications in Robust Learning
职业:结构化极小极大优化:稳健学习中的理论、算法和应用
- 批准号:
2338846 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Continuing Grant
CRII: SaTC: Reliable Hardware Architectures Against Side-Channel Attacks for Post-Quantum Cryptographic Algorithms
CRII:SaTC:针对后量子密码算法的侧通道攻击的可靠硬件架构
- 批准号:
2348261 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Standard Grant
CRII: AF: The Impact of Knowledge on the Performance of Distributed Algorithms
CRII:AF:知识对分布式算法性能的影响
- 批准号:
2348346 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Standard Grant
CRII: CSR: From Bloom Filters to Noise Reduction Streaming Algorithms
CRII:CSR:从布隆过滤器到降噪流算法
- 批准号:
2348457 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Standard Grant
EAGER: Search-Accelerated Markov Chain Monte Carlo Algorithms for Bayesian Neural Networks and Trillion-Dimensional Problems
EAGER:贝叶斯神经网络和万亿维问题的搜索加速马尔可夫链蒙特卡罗算法
- 批准号:
2404989 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Standard Grant
CAREER: Efficient Algorithms for Modern Computer Architecture
职业:现代计算机架构的高效算法
- 批准号:
2339310 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Continuing Grant
CAREER: Improving Real-world Performance of AI Biosignal Algorithms
职业:提高人工智能生物信号算法的实际性能
- 批准号:
2339669 - 财政年份:2024
- 资助金额:
$ 16.46万 - 项目类别:
Continuing Grant