Genetic and Neural Complexity in Psychiatry

描述（由申请人提供）：精神病学遗传学领域的最新进展带来了兴奋和迫切需要设想和设计智能的下一步，以便为精神疾病的神经生物学提供信息，并制定预防，早期干预或治疗的策略。“精神病学中的遗传和神经复杂性”会议的主要目标是促进对精神病学研究未来的讨论，因为它受到遗传学的最新进展和神经科学中新出现的概念和方法的影响。这次会议将汇集专家，并开启遗传学家和神经科学家之间的对话，允许直接翻译和快速应用最近的发现。在计划召开的三次双年会系列会议中，第一次会议将重点关注深度测序方法，这将允许发现罕见的、高渗透的突变，以及旨在了解它们对基因功能影响的方法，包括小鼠模型的生成。它还将讨论新兴的重编程技术，这些技术允许从携带特定罕见突变的患者身上开发细胞模型，以及研究其他动物物种（特别强调非人类灵长类动物）的利弊。最后，它将强调和讨论新的方法来破译电路和通信在疾病的大脑。

DESCRIPTION (provided by applicant): Recent advances in the field of psychiatric genetics have brought about excitement and urgency to envision and design intelligently the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment. The primary goal of the meeting on the "Genetic and Neural Complexity in Psychiatry" is to facilitate a discussion on the future of research in Psychiatry as it is shaped by the recent advances in genetics and newly emerging concepts and approaches in neuroscience. This meeting will bring together experts and open a dialogue between geneticists and neuroscientists allowing direct translation and speedy application of recent findings. The first planned meeting in the proposed series of 3 bi-annual meetings, will focus on deep sequencing approaches, which will allow discovery of rare, highly penetrant mutations, as well as on approaches designed to understand their impact on gene function, including the generation of mouse models. It will also address emerging reprogramming technologies that allow development of cellular models from patients carrying specific rare mutations as well as the pros and cons of studying additional animal species with particular emphasis on non-human primates. Finally, it will highlight and discuss novel approaches to decipher circuitry and communication in the disease brain. PUBLIC HEALTH RELEVANCE: This meeting brings together pre-eminent experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, and psychiatry, to identify issues of importance, and set goals and standards for the critical advancement of the field of Psychiatry. The time is opportune, since recent advances in the field of psychiatric genetics call for careful planning of the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment.