Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?
Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?
批准号:
8321109
负责人:
JEROEN ROOSE
金额:
$25.76万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2012-08-31
关键词:
AffectAffinityAllelesAntibodiesAutoimmune DiseasesB-LymphocytesBiochemicalBiological AssayBiological ProcessC-terminalCalciumCalcium BindingCell LineCell LineageCell physiologyCellsCharacteristicsChargeChemicalsCommunitiesComplexComputer SimulationCuesCytokine ReceptorsDataDefectDevelopmentDimerizationDiscriminationEF Hand MotifsEthylnitrosoureaExtracellular Signal Regulated KinasesGenerationsGlycineGoalsHumanImmuneImmune System DiseasesImmunologyIn VitroLeadLigationLymphoidLymphoid CellMAPK14 geneMAPK8 geneMEKsMalignant NeoplasmsMissionMitogen-Activated Protein KinasesModelingMolecularMonomeric GTP-Binding ProteinsMusMutationMyeloid CellsOrganPathway interactionsPatternPeptide/MHC ComplexPeripheralPhenotypePhysiologicalPlayPoint MutationProcessProteinsPublicationsPublishingRegulationReportingResearchResearch PersonnelRoleSignal TransductionSon of Sevenless ProteinsStimulusT-Cell LeukemiaT-Cell LymphomaT-Cell ReceptorT-LymphocyteTestingThymocyte DevelopmentThymocyte SelectionThymus GlandUbiquitinationUnited States National Institutes of Healthanalogbasecancer cellcell typedigitaldimerin vivoinhibitor/antagonistinsightmouse modelnoveloverexpressionprotein degradationras Guanine Nucleotide Exchange Factorsreceptorreconstitutionresearch studyresponsesmall hairpin RNAthymocytetool
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Project 2
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Project 2
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Molecular understanding of cytokine-Ras signals in leukemic bone marrow
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Molecular understanding of cytokine-Ras signals in leukemic bone marrow
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Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence
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财政年份:2015
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Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence
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项目类别:
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财政年份:2014
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依托单位:
Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
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项目类别:
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财政年份:2014
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财政年份:2013
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负责人:JEROEN ROOSE
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Non-linear transduction of TCR signals leading to Ras activation
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Canonical and non-canonical RasGEF pathways in T cells
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项目类别:
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资助金额:$39.47万
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财政年份:2011
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负责人:JEROEN ROOSE
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依托单位:
Canonical and non-canonical RasGEF pathways in T cells
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批准号:10615836
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项目类别:
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资助金额:$40.23万
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财政年份:2011
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负责人:JEROEN ROOSE
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依托单位:
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项目类别:
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依托单位:
Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
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批准号:10428135
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项目类别:
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资助金额:$199.99万
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财政年份:2011
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负责人:JEROEN ROOSE
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Non-linear transduction of TCR signals leading to Ras activation
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依托单位:
Understand the metabolic fitness of naïve T cells
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财政年份:2011
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依托单位:
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依托单位:
海外基金