Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?

Ras-MAPK 信号的机制研究：T 细胞谱系的特殊线索？

• 批准号: 8321109
• 负责人: JEROEN ROOSE
• 金额: $ 25.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321109
• 关键词: Affect; Affinity; Alleles; Antibodies; Autoimmune Diseases; B-Lymphocytes; Biochemical; Biological Assay; Biological Process; C-terminal; Calcium; Calcium Binding; Cell Line; Cell Lineage; Cell physiology; Cells; Characteristics; Charge; Chemicals; Communities; Complex; Computer Simulation; Cues; Cytokine Receptors; Data; Defect; Development; Dimerization; Discrimination; EF Hand Motifs; Ethylnitrosourea; Extracellular Signal Regulated Kinases; Generations; Glycine; Goals; Human; Immune; Immune System Diseases; Immunology; In Vitro; Lead; Ligation; Lymphoid; Lymphoid Cell; MAPK14 gene; MAPK8 gene; MEKs; Malignant Neoplasms; Mission; Mitogen-Activated Protein Kinases; Modeling; Molecular; Monomeric GTP-Binding Proteins; Mus; Mutation; Myeloid Cells; Organ; Pathway interactions; Pattern; Peptide/MHC Complex; Peripheral; Phenotype; Physiological; Play; Point Mutation; Process; Proteins; Publications; Publishing; Regulation; Reporting; Research; Research Personnel; Role; Signal Transduction; Son of Sevenless Proteins; Stimulus; T-Cell Leukemia; T-Cell Lymphoma; T-Cell Receptor; T-Lymphocyte; Testing; Thymocyte Development; Thymocyte Selection; Thymus Gland; Ubiquitination; United States National Institutes of Health; analog; base; cancer cell; cell type; digital; dimer; in vivo; inhibitor/antagonist; insight; mouse model; novel; overexpression; protein degradation; ras Guanine Nucleotide Exchange Factors; receptor; reconstitution; research study; response; small hairpin RNA; thymocyte; tool