课题基金 / 基金详情

Gender-Specific Role of Aim2 in Inflammation and Autoimmunity

Gender-Specific Role of Aim2 in Inflammation and Autoimmunity
Aim2 在炎症和自身免疫中的性别特异性作用
批准号：
8317789
负责人：
DIVAKER CHOUBEY
金额：
$39.25万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-01 至 2014-08-31
来源：
https://reporter.nih.gov/project-details/8317789
关键词：
1q21AIM2 geneAndrogen ReceptorAndrogensAntibodiesAntibody FormationApoptosisArthritisAutoimmune DiseasesAutoimmunityBacterial InfectionsBindingBiochemicalBiological AssayCaspase-1Cell DeathCell LineCellsCellular biologyChromosomes, Human, Pair 1ChronicCollagenCytoplasmDefectDiseaseFamilyFemaleGenderGene ClusterGenerationsGenesGeneticGenetic PolymorphismGenetic TranscriptionGonadal Steroid HormonesHormonesHumanIRF3 geneImmuneImmune responseImmune systemIn VitroInfectionInflammationInflammatoryInterferon Type IInterferonsInterleukin-1Interleukin-18Knockout MiceLupusMediatingMessenger RNAMolecularMouse StrainsMusNew ZealandNuclearNucleic AcidsPatientsPattern recognition receptorPhosphorylationPlayPredispositionProtein BindingProtein FamilyProteinsRecruitment ActivityRegulationReportingRoleSTAT1 geneSex BiasSignal TransductionSystemic Lupus ErythematosusTranscriptional ActivationVirus DiseasesWild Type Mouseadapter proteinanti-dsDNA antibodiesbasechromatin immunoprecipitationcytokinedesignds-DNAgene repressionin vivomacrophagemalemarenostrinmembermicrobialnovelpathogenpromoterpublic health relevanceresponsesensor

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