Nucleic Acid Binding Polymers as Anti-Inflammatory Agents

作为抗炎剂的核酸结合聚合物

• 批准号: 8309507
• 负责人: BRUCE ALAN SULLENGER
• 金额: $ 39.25万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8309507
• 关键词: Alzheimer' s Disease; American; Anti-Inflammatory Agents; Anti-inflammatory; Applications Grants; Attenuated; Autoantibodies; Autoimmune Diseases; Autoimmune Process; Binding; Biocompatible Materials; CCL4 gene; Cell Culture Techniques; Cells; Chemistry; Clinical; Complex; Cytosine; DNA; Development; Disease; Disease Progression; Disease model; Double-Stranded RNA; Drug Design; Engineering; Family; Guanine; Human; Immune; Inbred NZB Mice; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Injury; Interferon Type I; Interferons; Interleukin-6; Kidney; Knowledge; Lead; Ligands; Liver; Mediating; Modeling; Molecular; Molecular Profiling; Multiple Sclerosis; Mus; Nucleic Acid Binding; Nucleic Acids; Pathogenesis; Pathology; Patients; Pattern; Pattern recognition receptor; Pharmaceutical Preparations; Polymers; Production; Property; Psoriasis; RNA; Rheumatoid Arthritis; Sepsis; Serum; Signal Transduction; Staging; Stimulus; Structure; Systemic Lupus Erythematosus; TLR3 gene; TLR7 gene; TLR8 gene; TNF gene; Testing; Therapeutic Agents; Tissues; Toll-like receptors; Toxic effect; Treatment Efficacy; base; cell injury; clinically significant; cytokine; design; extracellular; human disease; improved; inorganic phosphate; mouse model; non-viral gene delivery; novel; novel strategies; pathogen; prevent; prototype; receptor; receptor binding; sensor; uptake

项目成果

Nucleic acid-binding polymers as anti-inflammatory agents: reducing the danger of nuclear attack.

核酸结合聚合物作为抗炎剂：减少核攻击的危险。

• DOI: 10.1586/eci.11.82
• 发表时间: 2012
• 期刊: Expert review of clinical immunology
• 影响因子: 4.4
• 作者: Pisetsky,DavidS;Lee,Jaewoo;Leong,KamW;Sullenger,BruceA
• 通讯作者: Sullenger,BruceA

The origin and properties of extracellular DNA: from PAMP to DAMP.

• DOI: 10.1016/j.clim.2012.04.006
• 发表时间: 2012-07
• 期刊: Clinical immunology (Orlando, Fla.)
• 作者: Pisetsky DS