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ANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAY

ANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAY
针对 HDAC6/HSP90 通路的抗炎作用
批准号：
8308760
负责人：
Wayne William Hancock
金额：
$20.94万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-08-15 至 2013-07-31
来源：
https://reporter.nih.gov/project-details/8308760
关键词：
AcetylationAcetyltransferaseAddressAdoptive TransferAdrenal Cortex HormonesAllograftingAmericanAnti-Inflammatory AgentsAnti-inflammatoryAutoimmune DiseasesAutoimmunityBlocking AntibodiesCanis familiarisCell physiologyCellsCellular StressChromatinChronicClientColitisComplexCrohn&aposs diseaseCytoplasmDNA MethyltransferaseDNA Modification MethylasesDataDeacetylaseDevelopmentDisease modelEnzymesEpigenetic ProcessExcisionExhibitsExperimental ModelsFundingGene ExpressionGene Expression RegulationGenetic TranscriptionGraft RejectionHDAC6 geneHDAC7 histone deacetylaseHeat shock proteinsHeat-Shock Proteins 70Heat-Shock Proteins 90Histone Deacetylase InhibitorHistonesImmuneImmunocompetentImmunosuppressionImmunosuppressive AgentsIn VitroIncidenceInflammationInflammatoryInflammatory Bowel DiseasesInflammatory ResponseInfusion proceduresLong-Term EffectsLysineMaintenanceMediatingModelingMultiple MyelomaMusMutagenesisNeurodegenerative DisordersNuclearOrgan TransplantationOutcomePathway interactionsPatientsPhysiciansPrizeProtein IsoformsProteinsRegulationRegulatory T-LymphocyteResearchResistanceRiskRoleScientistTNF geneTailTherapeutic EffectTherapeutic InterventionToxic effectUp-RegulationWild Type MouseWorkallograft rejectionbasecell motilitychromatin remodelingclinical applicationin vivoinhibitor/antagonistinnovationinsightinterestnephrotoxicitynovel therapeuticsoncologypost-transplant diseasepreventprotein misfoldingprotein protein interactionresponsetherapeutic developmenttherapeutic targettumor

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