INFLUENCE OF DIET ON DEVELOPMENT OF INTESTINAL MICROBIOTA

饮食对肠道菌群发育的影响

• 批准号: 8356741
• 负责人: James Versalovic
• 金额: $ 2.05万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356741
• 关键词: Age; Asphyxia Neonatorum; Bacteria; Birth; Clinical Research; Comorbidity; Data; Development; Diet; Enrollment; Environment; Feces; Funding; Grant; Hospitals; Hour; Human Milk; Intestines; Methods; Milk; National Center for Research Resources; Necrotizing Enterocolitis; Neonatal Intensive Care Units; Premature Infant; Principal Investigator; Probiotics; Relative (related person); Research; Research Infrastructure; Resources; Sampling; Sepsis; Source; Texas; United States National Institutes of Health; cost; feeding; neonate; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: The development of the intestinal microbiota is influenced by factors such as age, diet, and environment. There is limited data on intestinal bacterial colonization among hospitalized premature infants. Objectives: The study aims to describe and compare the development of intestinal microbiota among hospitalized premature infants receiving different types of milk. Methods: Neonates weighing 1000-1500 grams admitted to Texas Childrens Hospital Neonatal Intensive Care Unit (TCH NICU) within the first forty-eight hours from birth will be enrolled in the study. Neonates with congenital anomalies and perinatal asphyxia will be excluded. There will be three groups of neonates namely: expressed breast milk group, donor milk group and the formula milk group. Stool samples will analyzed for types of bacteria and relative amounts of bacteria over a period of six weeks. Expressed breast milk will be evaluated for presence of bacteria with probiotic potential and for pathogen. The occurrence of co-morbidities such as feeding intolerance, early and late onset sepsis and necrotizing enterocolitis will be compared among the three groups.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 背景：肠道菌群的发育受年龄、饮食和环境等因素的影响。住院早产儿肠道细菌定植的数据有限。目的：该研究旨在描述和比较接受不同类型牛奶的住院早产儿肠道微生物群的发展。 研究方法：体重1000-1500 g的新生儿在出生后48小时内入住德克萨斯州儿童医院新生儿重症监护室（TCH NICU），将入组本研究。将排除先天性异常和围产期窒息的新生儿。新生儿将分为三组，即：挤出母乳组、供体奶组和配方奶组。粪便样本将在六周内分析细菌类型和细菌的相对数量。将评价挤出的母乳中是否存在具有益生菌潜力的细菌和病原体。将比较三组间合并症的发生率，如喂养不耐受、早发型和晚发型脓毒症和坏死性小肠结肠炎。