NATIONAL REGISTRY OF GENETICALLY TRIGGERED THORACIC AORTIC ANEURYSMS

国家基因触发胸主动脉瘤登记处

• 批准号: 8356739
• 负责人: SCOTT A LEMAIRE
• 金额: $ 0.24万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356739
• 关键词: Aneurysm; Aortic Aneurysm; Aortic Rupture; Bioinformatics; Blood specimen; Cardiovascular system; Characteristics; Clinical; Clinical Management; Clinical Research; Data; Data Analyses; Development; Dissection; Equipment and supply inventories; Funding; Genetic; Goals; Grant; Medical; Methods; National Center for Research Resources; Operative Surgical Procedures; Outcome; Patients; Principal Investigator; Publishing; Registries; Research; Research Infrastructure; Research Personnel; Resources; Risk; Source; Specimen; Thoracic Aortic Aneurysm; Tissue Sample; United States National Institutes of Health; cost; interest; patient registry; repaired; tissue processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of GenTAC is to establish a registry of patients with genetically induced thoracic aortic aneurysms and related conditions, and collect associated medical data, as well as blood and tissue samples. The registry will establish a biospecimen inventory and bioinformatics infrastructure that will enable research to determine best medical practices to advance the clinical management of genetic thoracic aortic aneurysms, and other cardiovascular complications. To achieve these goals the registry will: 1) Develop standard methods to collect data and specimens which will be used for research to characterize patients at risk for aortic rupture and dissection, and development of other cardiovascular complications. 2) Record the characteristics of patients undergoing surgical repair of aneurysms and their clinical outcomes 3) Process tissue and blood specimens 4) Analyze data collected 5) Provide access to these resources to Registry investigators and outside researchers who are interested in advancing the fundamental understanding of genetic aortic aneurysms and management of afflicted patients 6) Publish and disseminate results.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 GenTAC 的总体目标是建立遗传性胸主动脉瘤及相关病症患者的登记册，并收集相关的医疗数据以及血液和组织样本。该登记处将建立生物样本库存和生物信息学基础设施，使研究能够确定最佳医疗实践，以推进遗传性胸主动脉瘤和其他心血管并发症的临床管理。为了实现这些目标，登记处将： 1) 开发标准方法来收集数据和样本，这些数据和样本将用于研究，以确定有主动脉破裂和夹层风险以及发生其他心血管并发症的患者的特征。 2) 记录接受动脉瘤手术修复的患者的特征及其临床结果 3) 处理组织和血液标本 4) 分析收集的数据 5) 向注册研究人员和有兴趣增进对遗传性主动脉瘤和患病患者管理的基本了解的外部研究人员提供这些资源的访问权限 6) 发布和传播结果。