Program for HIV Prevention and Treatment-Clinical Trial Unit, Thailand

泰国艾滋病毒预防和治疗计划临床试验中心

• 批准号: 8019531
• 负责人: Gonzague Joseph Jourdain
• 金额: --
• 依托单位: INSTITUTE OF RESEARCH AND DEVELOPMENT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8019531
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adult; Affect; Anti-Retroviral Agents; Area; Child; Clinical Research; Clinical Trials; Clinical Trials Unit; Collaborations; Communities; Environment; Guidelines; HIV; HIV Infections; Health Personnel; Healthcare Systems; Hospitals; IMPAACT; International; Knowledge; Leadership; Methods; Mission; Monitor; Patients; Population; Public Health; Public Hospitals; Research; Research Activity; Research Infrastructure; Research Personnel; Site; Structure; Thailand; Vertical Disease Transmission; base; caregiving; clinical research site; cohort; follow-up; improved; prevent; programs; scale up; treatment program

DESCRIPTION (provided by applicant): The PHPT research group was created in 1996 in Thailand, with the mission to develop strategies for preventing mother-to-child transmission of HIV, and methods of treating AIDS that could be integrated in the existing health care system in order to reach the populations who needed it most. The collaboration between the clinical trial unit, 37 public hospitals and the Ministry of public Health resulted in the completion of two major PMTCT studies that form the basis of the WHO and Thai national guidelines on PMTCT. Following previous collaboration with PACTG, the PHPT-CTU will continue to address outstanding issues that have been targeted by the IMPAACT leadership network. Within the context of rapid scale up of antiretroviral treatment programs in Thailand, PHPT has started a treatment monitoring strategy trial (PHPT-3) and organized a structured follow up of a large cohort of patients on treatment, and strengthened the involvement of the communities in these research activities. Therefore another area of focus for the PHPT CTU will be optimization of treatments in adults and adolescents. The organization of PHPT has demonstrated its ability to successfully conduct large clinical trials. The PHPT group has selected the 10 strongest clinical research sites to implement international studies with the leadership networks. These sites have access to large affected populations and have the expertise and infrastructure to carryout these studies, as well as contributing to the research agenda of the networks. The participation in the networks will add to the existing international collaborations to provide an environment conducive to the promotion of new investigators and clinical research staff in Thailand to sustain HIV research efforts. The research agenda to which the PHPT-CTU intends to contribute will have a major public health impact not only in Thailand but also for all communities affected by HIV. The sites participating in this research are Bhumibol Adulyadej Hospital, Chonburi Hospital, Hat Yai Hospital, Maharaj Nakorriratchasrima Hospital, Nakhonpathom Hospital, Nakornping Hospital, Phayao Provincial Hospital, Drapokklao Hospital, Samutprakarn Hospital, and Samutsakorn Hospital. This research aims to develop more effective ways of preventing HIV infection in children and to improve methods to treat HIV infected adults, adolescents and children. It will also strengthen the expertise of the health care workers participating in the research in Thailand, and the knowledge produced will improve the care given in all affected areas. ADMINISTRATIVE COMPONENT:

描述（由申请人提供）： PHPT研究小组于1996年在泰国成立，其使命是制定预防艾滋病毒母婴传播的战略，以及治疗艾滋病的方法，这些方法可以整合到现有的医疗保健系统中，以覆盖最需要的人群。临床试验单位、37家公立医院和公共卫生部之间的合作导致完成了两项重大的防止母婴传播研究，这些研究构成了世卫组织和泰国关于防止母婴传播的国家准则的基础。在先前与PACTG合作之后，PHPT-CTU将继续解决IMPAACT领导网络所针对的未决问题。在泰国迅速扩大抗逆转录病毒治疗方案的背景下，公共卫生和公共卫生研究所启动了一项治疗监测战略试验（PHPT-3），并组织了一次对大量接受治疗的患者的结构性随访，并加强了社区对这些研究活动的参与。因此，PHPT CTU的另一个重点领域将是成人和青少年治疗的优化。 PHPT的组织已经证明了其成功进行大型临床试验的能力。PHPT小组选择了10个最强的临床研究中心，与领导网络一起实施国际研究。这些地点能够接触到大量受影响人口，并拥有开展这些研究的专门知识和基础设施，同时也有助于网络的研究议程。参加这些网络将加强现有的国际合作，提供一个有利于促进泰国新的研究人员和临床研究人员的环境，以维持艾滋病毒研究工作。PHPT-CTU打算为之做出贡献的研究议程将不仅对泰国而且对所有受艾滋病毒影响的社区产生重大的公共卫生影响。参与本研究的临床试验机构包括普密蓬·阿杜德医院、春武里医院、合艾医院、Maharaj Nakorriratchasrima医院、Nakhonpathom医院、Nakornping医院、法尧省医院、Drapokklao医院、Samutprakarn医院和Samutsakorn医院。 这项研究旨在开发更有效的预防儿童艾滋病毒感染的方法，并改进治疗感染艾滋病毒的成人、青少年和儿童的方法。它还将加强参与泰国研究的卫生保健工作者的专门知识，所产生的知识将改善所有受影响地区的护理。 行政部门：