Program for HIV Prevention and Treatment-Clinical Trial Unit, Thailand

说明(申请人提供)：1996年在泰国成立了预防艾滋病毒母婴传播研究小组，任务是制定预防艾滋病毒母婴传播的战略，以及可纳入现有卫生保健系统的治疗艾滋病的方法，以便接触到最需要的人口。临床试验单位、37家公立医院和公共卫生部之间的协作导致完成了两项主要的预防母婴传播研究，这两项研究构成了世卫组织和泰国关于预防母婴传播的国家准则的基础。在与太平洋反恐小组以前的合作之后，反恐小组将继续处理综合反恐行动领导网络针对的悬而未决的问题。在泰国迅速扩大抗逆转录病毒治疗方案的背景下，PHPT启动了治疗监测策略试验(PHPT-3)，并组织了对一大批接受治疗的患者进行有组织的跟踪，并加强了社区对这些研究活动的参与。因此，PHPT CTU的另一个重点领域将是优化成人和青少年的治疗。 PHPT的组织已经证明了它有能力成功地进行大型临床试验。PHPT小组选择了10个最强大的临床研究地点，与领先的网络一起实施国际研究。这些网站可以接触到大量受影响的人口，拥有开展这些研究的专门知识和基础设施，并为这些网络的研究议程做出贡献。加入这些网络将增加现有的国际合作，以提供一个有利于促进泰国新的研究人员和临床研究人员以维持艾滋病毒研究工作的环境。PHPT-CTU打算为之作出贡献的研究议程将不仅对泰国而且对所有受艾滋病毒影响的社区产生重大的公共卫生影响。参与这项研究的地点是普密蓬·阿杜德医院、春武里医院、Hat Yai医院、Maharaj Nakorriratachrima医院、Nakhonpathom医院、Nakornping医院、Phayao省医院、Drapoklao医院、SamutPrakarn医院和Samutsakorn医院。 这项研究旨在开发更有效的方法来预防儿童感染艾滋病毒，并改进治疗艾滋病毒感染的成人、青少年和儿童的方法。它还将加强参与泰国研究的卫生保健工作者的专业知识，所产生的知识将改善所有受影响地区的护理。 管理组件：

DESCRIPTION (provided by applicant): The PHPT research group was created in 1996 in Thailand, with the mission to develop strategies for preventing mother-to-child transmission of HIV, and methods of treating AIDS that could be integrated in the existing health care system in order to reach the populations who needed it most. The collaboration between the clinical trial unit, 37 public hospitals and the Ministry of public Health resulted in the completion of two major PMTCT studies that form the basis of the WHO and Thai national guidelines on PMTCT. Following previous collaboration with PACTG, the PHPT-CTU will continue to address outstanding issues that have been targeted by the IMPAACT leadership network. Within the context of rapid scale up of antiretroviral treatment programs in Thailand, PHPT has started a treatment monitoring strategy trial (PHPT-3) and organized a structured follow up of a large cohort of patients on treatment, and strengthened the involvement of the communities in these research activities. Therefore another area of focus for the PHPT CTU will be optimization of treatments in adults and adolescents. The organization of PHPT has demonstrated its ability to successfully conduct large clinical trials. The PHPT group has selected the 10 strongest clinical research sites to implement international studies with the leadership networks. These sites have access to large affected populations and have the expertise and infrastructure to carryout these studies, as well as contributing to the research agenda of the networks. The participation in the networks will add to the existing international collaborations to provide an environment conducive to the promotion of new investigators and clinical research staff in Thailand to sustain HIV research efforts. The research agenda to which the PHPT-CTU intends to contribute will have a major public health impact not only in Thailand but also for all communities affected by HIV. The sites participating in this research are Bhumibol Adulyadej Hospital, Chonburi Hospital, Hat Yai Hospital, Maharaj Nakorriratchasrima Hospital, Nakhonpathom Hospital, Nakornping Hospital, Phayao Provincial Hospital, Drapokklao Hospital, Samutprakarn Hospital, and Samutsakorn Hospital. This research aims to develop more effective ways of preventing HIV infection in children and to improve methods to treat HIV infected adults, adolescents and children. It will also strengthen the expertise of the health care workers participating in the research in Thailand, and the knowledge produced will improve the care given in all affected areas. ADMINISTRATIVE COMPONENT: