Program for HIV Prevention and Treatment-Clinical Trial Unit, Thailand

描述（由申请人提供）：PHPT研究小组于1996年在泰国成立，其使命是制定预防艾滋病毒母婴传播的战略和治疗艾滋病的方法，这些策略和方法可以整合到现有的卫生保健系统中，以达到最需要的人群。临床试验单位、37家公立医院和公共卫生部之间的合作完成了两项预防母婴传播的主要研究，这些研究构成了世卫组织和泰国预防母婴传播国家准则的基础。继之前与PACTG的合作之后，PHPT-CTU将继续解决IMPAACT领导网络所针对的悬而未决的问题。在泰国迅速扩大抗逆转录病毒治疗方案的背景下，PHPT启动了一项治疗监测战略试验（PHPT-3），并对大量接受治疗的患者组织了有组织的随访，并加强了社区对这些研究活动的参与。因此，PHPT CTU的另一个重点领域将是成人和青少年治疗的优化。

DESCRIPTION (provided by applicant): The PHPT research group was created in 1996 in Thailand, with the mission to develop strategies for preventing mother-to-child transmission of HIV, and methods of treating AIDS that could be integrated in the existing health care system in order to reach the populations who needed it most. The collaboration between the clinical trial unit, 37 public hospitals and the Ministry of public Health resulted in the completion of two major PMTCT studies that form the basis of the WHO and Thai national guidelines on PMTCT. Following previous collaboration with PACTG, the PHPT-CTU will continue to address outstanding issues that have been targeted by the IMPAACT leadership network. Within the context of rapid scale up of antiretroviral treatment programs in Thailand, PHPT has started a treatment monitoring strategy trial (PHPT-3) and organized a structured follow up of a large cohort of patients on treatment, and strengthened the involvement of the communities in these research activities. Therefore another area of focus for the PHPT CTU will be optimization of treatments in adults and adolescents. The organization of PHPT has demonstrated its ability to successfully conduct large clinical trials. The PHPT group has selected the 10 strongest clinical research sites to implement international studies with the leadership networks. These sites have access to large affected populations and have the expertise and infrastructure to carryout these studies, as well as contributing to the research agenda of the networks. The participation in the networks will add to the existing international collaborations to provide an environment conducive to the promotion of new investigators and clinical research staff in Thailand to sustain HIV research efforts. The research agenda to which the PHPT-CTU intends to contribute will have a major public health impact not only in Thailand but also for all communities affected by HIV. The sites participating in this research are Bhumibol Adulyadej Hospital, Chonburi Hospital, Hat Yai Hospital, Maharaj Nakorriratchasrima Hospital, Nakhonpathom Hospital, Nakornping Hospital, Phayao Provincial Hospital, Drapokklao Hospital, Samutprakarn Hospital, and Samutsakorn Hospital. This research aims to develop more effective ways of preventing HIV infection in children and to improve methods to treat HIV infected adults, adolescents and children. It will also strengthen the expertise of the health care workers participating in the research in Thailand, and the knowledge produced will improve the care given in all affected areas. ADMINISTRATIVE COMPONENT: