Development of HIV Vaccine Clinical Trials Phase I-II-III in Dominican Republic

描述（由申请人提供）：这个关于艾滋病毒疫苗试验单位的建议是为了填补多米尼加共和国艾滋病毒预防工作的空白。它的目标符合NIH的总体目标，即改善美国和国外的公共健康。该提案的具体目标如下：为了实现这些目标，我们制定了以下具体目标，这些目标支持HVTN领导力应用程序的一些具体目标： 1.通过以下方式促进研制有效的艾滋病毒疫苗： 开展临床试验，评估候选疫苗的安全性、免疫原性和有效性 促进艾滋病毒疫苗多中心研究接触特定高危人群 2.制定有效的社区教育计划，促进招募和保留HIV疫苗临床试验的目标人群。 3.通过旨在改变冒险行为的教育举措，为降低艾滋病毒感染率做出贡献。 4.促进对艾滋病毒/艾滋病的了解，努力减少对艾滋病毒/艾滋病感染者的羞辱和歧视。 5.提高对艾滋病疫苗研究的理解、接受和支持。 为了实现这一目标，我们建议设立一个艾滋病毒疫苗试验单位，进行第一、第二或第三阶段试验，以帮助通过预防性艾滋病毒疫苗，并执行一项社区教育方案，使社会、政治和科学界能够支持艾滋病毒疫苗研究和提高对艾滋病毒预防的认识。 行政部门：

DESCRIPTION (provided by applicant): This proposal for a HIV vaccine trials unit comes to fill an empty space in the HIV prevention effort in Dominican Republic. It objectives corresponds to NIH general objective of improve the public health in United States and abroad. The specific aims of this proposal are the following: In order to achieve these aims, we have developed the following specific objectives, which support some of the specific aims of the HVTN leadership application: 1. To contribute to the development of an effective vaccine against HIV by: Conducting clinical trials that evaluate the safety, immunogenicity, and efficacy of candidate vaccines Facilitating access to specific high risk populations for HIV vaccine multi-center studies 2. To develop an effective program of community education that facilitates the recruitment and retention of target population groups for HIV vaccine clinical trials. 3. To contribute to the reduction of HIV incidence through educational initiatives directed toward changing risk-taking behaviors. 4. To contribute to the understanding of HIV/AIDS in efforts to reduce the stigma and discrimination against people; who live with HIV/AIDS. 5. To increase the understanding, acceptance, and support for HIV vaccine research. To reach this aims we are proposing the establishment of an HIV Vaccine Trials Unit that perform phase I, II or III trials in order to help in the run through a preventive HIV vaccine as well as perform a community education program that allow the develop of social, political and scientific communities support to HIV vaccine research and the awareness about HIV prevention. ADMINISTRATIVE COMPONENT: