Role of dre-1/FBXO11 in apoptosis

描述（由申请人提供）：细胞凋亡的精确控制对生物体的存活至关重要。如果这一过程调节不当，可能导致发育缺陷、癌症、神经变性和过早衰老。细胞凋亡调控的分子机制在整个动物界的功能和序列中非常保守，并且在模式生物中的研究提供了与细胞死亡相关的人类疾病相关的大量信息。我已经发现了一个新的作用，保守的基因，dre-1/FBXO 11，在控制细胞凋亡的线虫秀丽隐杆线虫。我们有理由怀疑该基因在人类淋巴瘤的发病机制中具有重要作用。我的论文研究项目将涉及研究dre-1/FBXO 11的作用机制，希望能提高我们对凋亡调控的理解。生物学中一个令人惊讶的事实是，人类和其他生物体中的许多细胞都决定自杀。这是一个正常的过程，有助于在出生时产生发育良好的生物体，有助于防止异常的癌前细胞生长失控，并有助于产生可以对抗感染的免疫细胞。我们希望更好地了解这一决定是如何做出的，以便开发更好的治疗癌症和自身免疫性疾病（其中细胞不会在应该死亡的时候死亡）以及神经退行性疾病和衰老（其中细胞丢失应该存活）的方法。

DESCRIPTION (provided by applicant): The precise control of apoptosis is vital to the survival of an organism. If this process is improperly regulated, developmental defects, cancer, neurodegeneration and premature aging can result. The molecular mechanisms for apoptotic regulation are remarkably well-conserved in function and sequence across the animal kingdom, and studies in model organisms have provided an immense amount of information relevant to human diseases related to cell death. I have uncovered a novel role for a conserved gene, dre-1/FBXO11, in controlling apoptosis in the nematode Caenorhabditis elegans. We have reason to suspect that this gene is important for the pathogenesis of human lymphoma. My thesis research project will involve investigating the mechanism of dre-1/FBXO11 action in the hope of improving our understanding of apoptotic regulation. A surprising fact in biology is that many cells in humans and other organisms make the decision to commit suicide. This is a normal process that helps produce a properly-developed organism at birth, helps prevent abnormal pre-cancerous cells from growing out of control, and helps produce immune cells that can fight infection. We would like to better understand how this decision is made in order to develop better treatments for cancer and autoimmune disease (in which cells do not die when they should) and neurodegeneration and aging (in which cells are lost that should survive).