HIV AND SUBSTANCE ABUSE LABORATORY CORE

艾滋病毒和药物滥用实验室核心

• 批准号: 8357094
• 负责人: EDDY RIOS-OLIVARES
• 金额: $ 88.31万
• 依托单位: UNIVERSIDAD CENTRAL DEL CARIBE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357094
• 关键词: AIDS neuropathy; AIDS/HIV problem; Area; Biomedical Research; Buprenorphine; Cancer Vaccine Related Development; Cocaine; Communities; Community Services; Disease; Equipment; Funding; Government; Grant; HIV; Hepatitis C virus; Heroin; Human; Immune system; Immunologic Deficiency Syndromes; Laboratories; Mentors; Methadone; Methamphetamine; Methodology; National Center for Research Resources; Pharmaceutical Preparations; Pilot Projects; Population; Principal Investigator; Research; Research Activity; Research Infrastructure; Research Project Grants; Resources; Retroviridae; Services; Source; Structure; Substance abuse problem; Substance of Abuse; Testing; Translational Research; United States National Institutes of Health; addiction; base; cost; improved; instrumentation; meetings; programs; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The HIV and Substance of Abuse Laboratory Core (H-SALC) will continue providing human and physical resources needed to support studies in the areas of HIV/AIDS and related diseases as well as in substances of abuse. This support is extended to the Retrovirus Research Center, Center for Addiction Study, Comprehensive Center for the Study of HIV Disparities and other centers of the RCMI Program. In addition, it will continue with the existing collaborative activities with at least three communities and government based agencies. Furthermore, it will provide administrative and scientific support to pilot projects with the participation of consultants and mentors. Therefore, the research plan for the Renewal Proposal is directed toward: 1) Providing a centralized, well-structured laboratory supportive of research activities undertaken by centers and programs, including those handling infectious material and immunodeficiency diseases (HIV/AIDS, HCV, cancer, and vaccine development). 2) Improving and introducing new methodology to test the effect of addiction-related drugs (cocaine, heroin, methamphetamine and, methadone, and buprenorphine) on the immune system, the glial-neuro-network and HIV (i.e., NeuroAIDS), and HCV infectivity. 3) Upgrading and replacing obsolete instrumentation and acquiring new equipment to meet the increasing need of research projects for redirecting their methodology and making it more amenable to the translational research trend, 4) Strengthening existing and new affiliations with community service agencies to facilitate the involvement of specific disease populations in our research and services efforts, 5) Providing scientific and administrative support to pilot projects with the participation of consultants and mentors. To achieve these objectives, a research plan is discussed in the present proposal.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 艾滋病毒和滥用药物实验室核心将继续提供所需的人力和物力资源，以支持艾滋病毒/艾滋病和有关疾病以及滥用药物领域的研究。这种支持扩展到逆转录病毒研究中心，成瘾研究中心，艾滋病毒差异研究综合中心和RCMI计划的其他中心。 此外，它将继续与至少三个社区和政府机构开展现有的合作活动。 此外，它还将在顾问和导师的参与下，为试点项目提供行政和科学支助。 因此，更新提案的研究计划旨在：1）提供一个集中的、结构良好的实验室，支持中心和项目开展的研究活动，包括处理传染性物质和免疫缺陷疾病（HIV/AIDS、HCV、癌症和疫苗开发）的研究活动。2)改进和引入新的方法来测试成瘾相关药物（可卡因、海洛因、甲基苯丙胺和美沙酮以及丁丙诺啡）对免疫系统、神经胶质网络和艾滋病毒（即，NeuroAIDS）和HCV感染性。3)更新和更换过时的仪器，并购置新设备，以满足研究项目日益增长的需求，重新调整其方法，使其更适合转化研究的趋势，4）加强与社区服务机构的现有和新的联系，以促进特定疾病人群参与我们的研究和服务工作，5）在顾问和指导人员的参与下，为试点项目提供科学和行政支助。 为了实现这些目标，本提案中讨论了一项研究计划。