STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL

该合同的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，目标是预防因环境暴露于化学或物理剂而引起的疾病或不利影响。该合同涉及通过灌胃和皮肤途径对五种化学品进行慢性和慢性前研究，包括五溴二苯氧基（DE-71）；;吲哚- 3 -甲醇甲基苯乙烯酮；季戊四醇triacrylate;和三甲基丙烷三丙烯酸酯。对三丙烯酸季戊四醇、氧化五溴联苯和吲哚-3-甲醇进行了为期90天的研究。该合同取消了对季戊四醇三丙烯酸酯和吲哚-3甲醇为期2年的研究。2年甲基苯乙烯酮和三甲基丙烯三丙烯酸酯研究的生命期部分已经完成。正在对大鼠和小鼠进行为期2年的氧化五溴联苯慢性研究。在五溴二苯氧化慢性大鼠研究中，大鼠从妊娠第6天开始在子宫内治疗，持续到哺乳期，并将持续治疗至青春期至成年期。给药将持续到大鼠两岁，届时将对动物进行彻底的致癌性检查。

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This contract involes the prechronic and chronic studies of 5 chemicals by gavage and dermal routes including Pentabromodiphenyl oxide (DE-71); Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate. The 90-Day studies of Pentaerythritol triacrylate, Pentabromodiphenyl oxide and Indole-3-carbinol have been completed and reported. The 2-year studies for Pentaerythritol triacrylate and Indole-3 carbinol have been cancelled from this contract. The in-life portion of the 2-year Methyl styryl ketone and Trimethylolpropane triacrylate studies have been completed. Chronic 2 year studies on Pentabromodiphenyl oxide are ongoing in rats and mice. In the Pentabromodiphenyl oxide chronic rat study, rats have been treated in utero beginning on gestation day 6, continuing through the lactation period and will be continuously treated through puberty to adulthood. Dosing will continue until rats are two years of age at which time animals will be thoroughly examined for signs of carcinogenicity. Keywords Carcinogenicty; Toxicity; Wistar Han rats; Fisher rats; B6C3F1 mice; perinatal; triacrylates, flame retardants; Pentabromodiphenyl oxide; DE-71; Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate.