Phase 1 and Phase 2 Clinical Trials of Cancer Chemopreventive Agents

此次采购的目的是对国家癌症研究所(NCI)癌症预防部门(DCP)赞助的癌症预防药物进行多个早期阶段(第一阶段和第二阶段)临床试验，并建立由一个或多个将进行这些试验的合作机构组成的基础设施。这些试验将通过评估不同药物对其分子靶标的生物效应和确定临床相关因素来评估这些药物的癌症预防潜力。

The purpose of this procurement is to conduct multiple early phase (Phase 1 and Phase 2) clinical trials of the National Cancer Institute (NCI), Division of Cancer Prevention (DCP)-sponsored cancer preventive agents and to establish the infrastructures composed of one or more collaborating institutions that will perform these trials. The trials will assess the cancer preventive potential of various agents by evaluating the biologic effects of these agents on their molecular targets and by determining clinically relevant correlates.