CELL CULTURE AND ANIMAL MODELS CORE

细胞培养和动物模型 核心C，细胞培养和动物模型核心，是一个集成的，专门的，必不可少的组成部分 该计划将为该计划的所有四个项目提供材料和服务。此核心支持 这些项目通过提供专门的细胞培养设施、资源和专业知识，通过保持积极和 通过在需要时提供细胞培养技术培训，冻结项目使用的细胞系的库存 由项目中的研究人员，通过协助细胞培养实验或进行细胞培养 根据项目负责人的要求进行实验。此外，核心将监督一个SPF动物设施 可以在老鼠身上进行研究。这个菌落适合长期的遗传学研究。 改变小鼠、免疫缺陷(裸)小鼠和受辐射和/或药物抑制的小鼠 治疗。所需的设备、用品和专业知识，用于监测动物的肿瘤发展和 植入、测量和治疗肿瘤将在这个核心设施中提供。当项目需要时 领导，核心将维护小鼠品系和动物肿瘤模型系统，将培训项目工作人员在 技术，并将参与这些模型系统的设计、性能和分析 使用这些小鼠模型系统进行实验。

Core C. Cell Culture and Animal Models Core Core C, the Cell Culture and Animal Models Core, is an integrated, dedicated, essential component of the Program, which will provide materials and services to all four Projects of the Program. This Core supports the Projects by providing specialized cell culture facilities, resources and expertise, by maintaining active and frozen stocks of cell lines used by the Projects, by providing training in cell culture techniques when needed by researchersin the Projects, and by assisting with cell culture experiments or performing cell culture experiments when desired by the Program Leaders. In addition, the Core will oversee an SPF animal facility in which studies with mice can be performed. This colony is suitable for long term studies of genetically altered mice, immune deficient (nude) mice and mice immunosuppressed by irradiation and/or drug treatments. The equipment, supplies, and expertise needed to monitor animals for tumor development and to implant, measure,and treat tumors will be available in this Core facility. When desired by the Project Leaders, the Core will maintain mouse strains and animal tumor model systems, will train Project staff in the techniques used with these model systems, and will participate in the design, performance, and analysisof experiments using these mouse model systems.