CELL CULTURE AND ANIMAL MODELS CORE

核心 C. 细胞培养和动物模型核心 核心 C，即细胞培养和动物模型核心，是一个集成的、专用的、重要的组成部分 计划，将为该计划的所有四个项目提供材料和服务。该核心支持 通过提供专门的细胞培养设施、资源和专业知识，通过保持活跃和 项目使用的细胞系冷冻库存，在需要时提供细胞培养技术培训 由项目研究人员协助进行细胞培养实验或进行细胞培养 当项目负责人需要时进行实验。此外，核心将监督 SPF 动物设施 可以用小鼠进行研究。该菌落适合于遗传的长期研究 变异小鼠、免疫缺陷（裸）小鼠和通过辐射和/或药物免疫抑制的小鼠 治疗。监测动物肿瘤发展和治疗所需的设备、用品和专业知识 该核心设施将提供植入、测量和治疗肿瘤的服务。当项目需要时 领导们，核心将维护小鼠品系和动物肿瘤模型系统，将培训项目人员 与这些模型系统一起使用的技术，并将参与设计、性能和分析 使用这些小鼠模型系统进行实验。

Core C. Cell Culture and Animal Models Core Core C, the Cell Culture and Animal Models Core, is an integrated, dedicated, essential component of the Program, which will provide materials and services to all four Projects of the Program. This Core supports the Projects by providing specialized cell culture facilities, resources and expertise, by maintaining active and frozen stocks of cell lines used by the Projects, by providing training in cell culture techniques when needed by researchersin the Projects, and by assisting with cell culture experiments or performing cell culture experiments when desired by the Program Leaders. In addition, the Core will oversee an SPF animal facility in which studies with mice can be performed. This colony is suitable for long term studies of genetically altered mice, immune deficient (nude) mice and mice immunosuppressed by irradiation and/or drug treatments. The equipment, supplies, and expertise needed to monitor animals for tumor development and to implant, measure,and treat tumors will be available in this Core facility. When desired by the Project Leaders, the Core will maintain mouse strains and animal tumor model systems, will train Project staff in the techniques used with these model systems, and will participate in the design, performance, and analysisof experiments using these mouse model systems.