CLINICAL TRIAL: A PHASE II STUDY OF REPEAT INTRANODAL INJECTIONS OF ADENOVIRUS-C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 主要目标 1)确定和监测重复结内注射Ad-ISF35的患者的临床和生物学反应。 次要目标 1)确定CLL/SLL患者淋巴结内直接注射Ad-ISF35的安全性。 2)测定重复结内注射Ad-ISF35的患者的药效学参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objectives 1)Determine and monitor clinical and biological responses in patients treated with repeat intranodal injections of Ad-ISF35. Secondary Objectives 1)Determine the safety of repeat administration of Ad-ISF35 injected directly into lymph nodes of patients with CLL / SLL. 2)Determine pharmacodynamic (PD) parameters in patients treated with repeat intranodal injections of Ad-ISF35.