CLINICAL TRIAL: A PHASE II STUDY OF REPEAT INTRANODAL INJECTIONS OF ADENOVIRUS-C

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 主要目标 1)确定并监测重复结内注射Ad-ISF 35治疗患者的临床和生物学反应。 次要目的 1)确定直接注射到CLL / SLL患者淋巴结中的Ad-ISF 35重复给药的安全性。 2)确定重复结内注射Ad-ISF 35治疗的患者的药效学（PD）参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objectives 1)Determine and monitor clinical and biological responses in patients treated with repeat intranodal injections of Ad-ISF35. Secondary Objectives 1)Determine the safety of repeat administration of Ad-ISF35 injected directly into lymph nodes of patients with CLL / SLL. 2)Determine pharmacodynamic (PD) parameters in patients treated with repeat intranodal injections of Ad-ISF35.