CARDIAC TROPONIN- T: A SPECIFIC BIOCHEMICAL MARKER OF MYOCARDIAL DYSFUNCTION, MO

心肌肌钙蛋白-T：心肌功能障碍的特定生化标志物，MO

• 批准号: 8174521
• 负责人: VIRENDER K REHAN
• 金额: $ 1.06万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174521
• 关键词: Adult; Age-Months; Biochemical Markers; Birth; Blood Tests; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Fetal Weight; Funding; Grant; Heart; Hospitals; Infant; Informed Consent; Institution; Measurement; Monitor; Mothers; Myocardial dysfunction; Outcome; Pregnant Women; Research; Research Personnel; Resources; Source; Testing; Time; Troponin; United States National Institutes of Health; Very Low Birth Weight Infant; heart function; heart imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to establish whether heart function in very low birth weight infants can be predicted by a simple blood test and whether this serial measurements of this test can predict overall outcome in very low birth infants .This blood test has been done in adults to detect damage in adults. It is hoped that this test will allow us to detect heart damage in very low birth infants earlier and provide us with more details on their long term outcome. This study will help us in better understanding of the heart function in very low birth weight infants and may provide a reliable blood test to not only monitor heart function but also to predict the ultimate outcome in very low birth weight infants. The babies enrolled will be lesser than 1500 gm. Pregnant women admitted to the hospital who have an estimated fetal weight <1500 g will be approached for informed consent for enrollment prior to delivery. If we are unable to approach mother prior to delivery, she will be approached after the delivery for enrollment. They will have special heart scans to look at their heart four times during the first week (Days 1,2,3, and 7 after delivery and at 1 month of age). Heart scans are routinely performed to detect heart problems in NICUs, and majority of very low birth infants have multiple heart scans performed during their stay in the NICU.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定是否可以通过简单的血液检查来预测极低出生体重儿的心脏功能，以及该测试的系列测量是否可以预测极低出生体重儿的总体结果。希望这项测试能够让我们更早地检测出极低出生婴儿的心脏损伤，并为我们提供有关其长期结局的更多细节。这项研究将有助于我们更好地了解极低出生体重儿的心脏功能，并可能提供一个可靠的血液检查，不仅监测心脏功能，而且预测极低出生体重儿的最终结果。 入组的婴儿将小于1500克。估计胎儿体重<1500 g的入院孕妇将在分娩前获得入组的知情同意书。如果我们无法在分娩前联系母亲，我们将在分娩后联系她进行入组。他们将在第一周进行四次特殊的心脏扫描（产后第1、2、3和7天以及1个月大时）。在新生儿重症监护病房（NICU）中，常规进行心脏扫描以检测心脏问题，大多数极低出生的婴儿在入住NICU期间进行多次心脏扫描。