CARDIAC TROPONIN- T: A SPECIFIC BIOCHEMICAL MARKER OF MYOCARDIAL DYSFUNCTION, MO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定是否可以通过简单的血液测试来预测极低出生体重儿的心功能，以及这种测试的系列测量是否可以预测极低出生体重儿的总体结局。这种血液测试是在成年人身上进行的，以检测成年人的损害。人们希望，这项测试将使我们能够更早地发现极低出生婴儿的心脏损伤，并为我们提供关于他们长期结局的更多细节。这项研究将有助于我们更好地了解极低出生体重儿的心功能，并可能为监测极低出生体重儿的心功能和预测最终结局提供可靠的血液检测方法。 登记的婴儿体重将低于1500克。入院的孕妇如果估计胎儿体重和体重为1500克，将在分娩前与其取得知情同意。如果我们无法在分娩前找到母亲，我们将在分娩后联系她进行注册。他们将在第一周(分娩后第1、2、3、7天和1个月大时)进行特殊的心脏扫描，检查心脏四次。心脏扫描是NICU中检测心脏问题的常规检查，大多数极低出生婴儿在NICU期间进行了多次心脏扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to establish whether heart function in very low birth weight infants can be predicted by a simple blood test and whether this serial measurements of this test can predict overall outcome in very low birth infants .This blood test has been done in adults to detect damage in adults. It is hoped that this test will allow us to detect heart damage in very low birth infants earlier and provide us with more details on their long term outcome. This study will help us in better understanding of the heart function in very low birth weight infants and may provide a reliable blood test to not only monitor heart function but also to predict the ultimate outcome in very low birth weight infants. The babies enrolled will be lesser than 1500 gm. Pregnant women admitted to the hospital who have an estimated fetal weight <1500 g will be approached for informed consent for enrollment prior to delivery. If we are unable to approach mother prior to delivery, she will be approached after the delivery for enrollment. They will have special heart scans to look at their heart four times during the first week (Days 1,2,3, and 7 after delivery and at 1 month of age). Heart scans are routinely performed to detect heart problems in NICUs, and majority of very low birth infants have multiple heart scans performed during their stay in the NICU.