FGF SIGNALING AND ZINC FINGER PROTEINS IN GONAD DEVELOPMENT AND REPRODUCTION

FGF 信号传导和锌指蛋白在性腺发育和生殖中的作用

• 批准号: 8167651
• 负责人: ZI-JIAN LAN
• 金额: $ 23.8万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167651
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Defect; Development; Female; Funding; Generations; Germ Cells; Gonadal structure; Grant; Human; Infertility; Institution; Minor; Mutant Strains Mice; Ovarian; Pathogenesis; Proteins; Reproduction; Research; Research Personnel; Resources; Role; Signal Transduction; Signaling Molecule; Source; United States National Institutes of Health; Zinc Fingers; insight; interest; male; mutant mouse model; smoothened signaling pathway

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research interest is to identify factors contributing to male and female subfertility and infertility. Our original project is to characterize the potential role of hedgehog signaling molecules patched 1 and suppressor of fused using Ptcmes/mes and Sufu+/-;Ptc1mes/mes in the ovarian development. Due to minor ovarian defects in those mutant mice, we have shifted our focus on the studies of other molecules including FGFRs and male germ cell-expressing zinc finger proteins in reproduction using mutant mouse models. Generation and functional analyses of these mutant mice will provide insight into the pathogenesis of human subfertility or infertility.

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