NEUROANATOMICAL CORRELATES OF READING DEVELOPMENT IN ADOLESCENTS WITH DYSLEXIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 阅读障碍是一种发育性疾病，影响多达17%的儿童(Shaywitz，1994)。在研究阅读障碍的神经生物学时，基于体素的形态计量学(VBM)研究表明，与正常读者相比，阅读困难读者左侧顶颞区和左侧枕颞区的灰质密度和体积减少(Brown等人，2001年；M.A.Eckert等人，2005年；Silani等人，2005年)。 具体目标： 利用VBM，这项纵向研究将在以往研究的基础上，通过检验阅读障碍青少年读者阅读发展的结构相关性来扩展。 方法： 对22例阅读障碍青少年进行了长达2.5年的随访。在基线和随访时测试参与者的智商和单词识别(WID)能力。在基线收集高分辨率解剖扫描，以进行优化和调制的VBM分析。对局部灰质和白质体积与Delta标准分数(Ss)进行了全脑回归分析，同时回归出基线年龄、智商和WID分数作为干扰变量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Dyslexia is a developmental condition that affects much as 17% of children (Shaywitz, 1994). In examining the neurobiology of dyslexia, voxel-based morphometry (VBM) studies have shown reduced gray matter density and volume in the left parieto-temporal and left occipito-temporal regions of dyslexic readers when compared to normal readers (Brown et al., 2001; M. A. Eckert et al., 2005; Silani et al., 2005). Specific Aims: Using VBM, this longitudinal study will extend upon previous studies by examining the structural correlates of reading development in adolescent dyslexic readers. Methods: Twenty two adolescents with dyslexia were followed up for 2.5 years. Participants' IQ and word identification (WID) abilities were tested at baseline and follow-up. High resolution anatomical scans were collected at baseline for optimized and modulated VBM analysis. Whole brain regression analyses between local gray and white matter volumes and delta standard scores (ss) were performed, while regressing out baseline age, IQ and WID scores as nuisance variables.