NEUROANATOMICAL CORRELATES OF READING DEVELOPMENT IN ADOLESCENTS WITH DYSLEXIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介： 阅读障碍是一种影响多达17%的儿童的发育状况（Shaywitz，1994）。在检查阅读障碍的神经生物学时，基于体素的形态测定（VBM）研究已经显示，与正常阅读者相比，阅读障碍者的左顶颞区和左枕颞区的灰质密度和体积减少（Brown等人，2001; M. A.埃克特等人，2005; Silani等人，2005年）。 具体目标： 本纵向研究将运用VBM对青少年阅读障碍者阅读发展的结构相关性进行研究。 研究方法： 对22例青少年阅读障碍患者进行了2.5年的随访。参与者的智商和单词识别（WID）能力在基线和随访时进行了测试。在基线时收集高分辨率解剖扫描，用于优化和调制的VBM分析。进行了局部灰质和白色物质体积与δ标准评分（ss）之间的全脑回归分析，同时回归出基线年龄、IQ和WID评分作为干扰变量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Dyslexia is a developmental condition that affects much as 17% of children (Shaywitz, 1994). In examining the neurobiology of dyslexia, voxel-based morphometry (VBM) studies have shown reduced gray matter density and volume in the left parieto-temporal and left occipito-temporal regions of dyslexic readers when compared to normal readers (Brown et al., 2001; M. A. Eckert et al., 2005; Silani et al., 2005). Specific Aims: Using VBM, this longitudinal study will extend upon previous studies by examining the structural correlates of reading development in adolescent dyslexic readers. Methods: Twenty two adolescents with dyslexia were followed up for 2.5 years. Participants' IQ and word identification (WID) abilities were tested at baseline and follow-up. High resolution anatomical scans were collected at baseline for optimized and modulated VBM analysis. Whole brain regression analyses between local gray and white matter volumes and delta standard scores (ss) were performed, while regressing out baseline age, IQ and WID scores as nuisance variables.