EFFECT OF CLA ON ONSET OF INFLAMMATION IN MODEL STUDIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议将共轭亚油酸用作鸡蛋孵化的抗炎剂。我们计划在先前识别急性炎症反应生物标志物的研究的基础上，检测孵化鸡的早期炎症。我们计划系统地定义和具体重建我们开发的代谢分析方法，以便在鸡模型研究中快速识别早期和可靠的出生后炎症生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use CLA as anti-inflammatory agent in chicken eggs hatchlings. We plan to detect early onset of inflammation in hatched chickens based on previous studies identifying biomarkers of acute inflammatory response. We plan to systematically define and specifically reconstruct the metabolic analysis methodology we have developed to rapidly identify early and reliable biomarkers of inflammation after birth in chicken model studies.