STRUCTURAL STUDIES OF RECEPTOR ACTIVATION

受体激活的结构研究

• 批准号: 8169298
• 负责人: ANDREW B HERR
• 金额: $ 1.4万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169298
• 关键词: Adhesions; Antibodies; Cell Adhesion; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; IgA receptor; Immunoglobulin A; Immunology; Institution; Laboratory Study; Mediating; Microbial Biofilms; Pathogenesis; Platelet Activation; Proteins; Receptor Activation; Research; Research Personnel; Resources; Source; Thrombosis; United States National Institutes of Health; Work; inhibitor/antagonist; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My laboratory studies mechanisms of receptor activation and cellular adhesion related to immunology, thrombosis, and bacterial pathogenesis. In particular, we are working on: 1) interactions between IgA antibodies and IgA receptors, 2) receptor-mediated platelet activation and thrombosis inhibitors, 3) protein-dependent intercellular adhesion in staphylococcal biofilms.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我的实验室研究与免疫学、血栓形成和细菌发病机制相关的受体激活和细胞粘附机制。 特别是，我们正在研究：1）伊加抗体和伊加受体之间的相互作用，2）受体介导的血小板活化和血栓形成抑制剂，3）葡萄球菌生物膜中的蛋白质依赖性细胞间粘附。