STRUCTURAL STUDIES OF RECEPTOR ACTIVATION

受体激活的结构研究

• 批准号: 8169298
• 负责人: ANDREW B HERR
• 金额: $ 1.4万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169298
• 关键词: Adhesions; Antibodies; Cell Adhesion; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; IgA receptor; Immunoglobulin A; Immunology; Institution; Laboratory Study; Mediating; Microbial Biofilms; Pathogenesis; Platelet Activation; Proteins; Receptor Activation; Research; Research Personnel; Resources; Source; Thrombosis; United States National Institutes of Health; Work; inhibitor/antagonist; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My laboratory studies mechanisms of receptor activation and cellular adhesion related to immunology, thrombosis, and bacterial pathogenesis. In particular, we are working on: 1) interactions between IgA antibodies and IgA receptors, 2) receptor-mediated platelet activation and thrombosis inhibitors, 3) protein-dependent intercellular adhesion in staphylococcal biofilms.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我的实验室研究机制与免疫学，血栓形成和细菌发病机理有关的受体激活和细胞粘附机制。 特别是，我们正在研究：1）IgA抗体与IgA受体之间的相互作用，2）受体介导的血小板激活和血栓形成抑制剂，3）葡萄球菌生物膜中蛋白质依赖性细胞间粘附。